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Ph-sensitive hydrogen and its production

A hydrogel and sensitive technology, which is applied in the field of pH-sensitive hydrogel and its preparation, can solve the problems that PNIPAAm hydrogel cannot be degraded in vivo and limit its application, and achieve potential application value, high adhesion and softness properties, good pH sensitivity

Inactive Publication Date: 2007-11-21
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the cross-linked PNIPAAm hydrogel itself cannot be degraded in vivo, which greatly limits its application.
Currently, there is no report on the preparation of pH-sensitive biodegradable PVME / CMCS hydrogels using semi-IPN technology.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: 0.1M carboxymethyl chitosan and 0.1M polymethyl vinyl ether were mixed in a volume ratio of 15:15, magnetically stirred for 120 minutes, fully mixed, and 0.75ml of 1wt% pentadiene was added dropwise Aldehyde, continue to stir and react for 1h, and after standing for 5 minutes, cast a film in a polytetrafluoroethylene mold, and volatilize to a constant weight at room temperature. The resulting hydrogel has an equilibrium swelling degree of 1395% at pH=1.0 at 20°C, an equilibrium swelling degree of 185% at pH=3.0, a 544% equilibrium swelling degree at pH=4.4, and an equilibrium swelling degree of at pH=7.4. The equilibrium swelling degree is 1622%.

Embodiment 2

[0015] Example two: 0.1M carboxymethyl chitosan and 0.1M polymethyl vinyl ether were mixed in a volume ratio of 12:18, magnetically stirred for 120 minutes, fully mixed, and 0.6ml of 1wt% pentadiene was added dropwise Aldehyde, continue to stir and react for 1h, and after standing for 5 minutes, cast a film in a polytetrafluoroethylene mold, and volatilize to a constant weight at room temperature. The equilibrium swelling degrees of the obtained hydrogel at 20°C and pH=1.0, 3.0, 4.4 and 7.4 were 630%, 322%, 129% and 409%, respectively.

Embodiment 3

[0016] Embodiment three: 0.1M carboxymethyl chitosan and 0.1M polymethyl vinyl ether were mixed in a ratio of 18:12 in molar ratio, magnetically stirred for 120 minutes to make it fully mixed, and 0.9ml of 1wt% pentamethylenediene was added dropwise Aldehyde, continue to stir and react for 1h, and after standing for 5 minutes, cast a film in a polytetrafluoroethylene mold, and volatilize to a constant weight at room temperature. The equilibrium swelling degrees of the obtained hydrogel at 20°C and pH=1.0, 3.0, 4.4 and 7.4 were 1052%, 93%, 330% and 1458%, respectively.

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PUM

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Abstract

A pH sensitive hydrogel and its production are disclosed. The hydrogel consists of carboxy-methyl chitose, poly-methyl-vinyl ether, cross-linking agent glutaric dialdehyde and water. The proportion of carboxy-methyl chitose: poly-methyl-vinyl ether is 1:0.25-1.5 mol; proportion of cross-linking glutaric dialdehyde: carboxy-methyl chitose is 1:10-30 mol, residue is water. The production is carried out by agitating, dissolving carboxy-methyl chitose and poly-methyl-vinyl ether into deionized water in proportion of 1:0.25-1.5 mol, mixing, controlling concentration of them between 0.05-0.1 M, dripping glutaric dialdehyde into mixed solution in proportion of 1:10-30 mol, agitating while reacting for 30-60 mins, laying aside, pouring it into mould, drying at room temperature and weighing to obtain semi-penetrating network pH sensitive hydro-gel. It has excellent sensitivity, adhesion, flexibility and degradability. It can be used as medicine slow-releasing carrier.

Description

technical field [0001] The invention relates to a pH-sensitive hydrogel and a preparation method thereof, in particular to a pH-sensitive hydrogel with a semi-interpenetrating network structure and a preparation method thereof. Background technique [0002] Polymer gel refers to a macromolecular network filled with liquid, which is composed of polymers with a network structure and solvents. It is a three-dimensional network between liquid and solid, which has both liquid-like mobility and fluidity, and solid-like shape stability. When the macromolecular skeleton is hydrophilic, the liquid it fills can be water or an aqueous solution. This gel is called a hydrophilic gel, or hydrogel for short. [0003] Smart hydrogels are a class of hydrogels that respond to subtle changes in the external environment (such as temperature, pH, ionic strength, light, and specific chemical substances, etc.). pH-sensitive hydrogel is a polymer hydrogel whose volume changes with the pH value of...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/08C08L29/10
Inventor 尹静波郁杨颜世峰谢勇涛罗坤马嘉陈学思
Owner SHANGHAI UNIV
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