Preparation method of physically-crosslinked chitosan-based hydrogel with efficient pH sensitivity and high mechanical strength

A technology of mechanical strength and chitosan, which is applied in the field of preparation of physically cross-linked chitosan-based hydrogel, can solve the problems of poor mechanical properties and slow response to external stimuli, and achieve strong mechanical properties, easy mixing and heat dissipation , the effect of mild reaction conditions

Inactive Publication Date: 2018-01-23
SHANDONG UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

[0004] Aiming at the problems of slow response to external stimuli and poor mechanical properties in current pH-sensitive physical cross-linked hydrogels, the purpose of the present invention is to provide a novel preparation method of pH-sensitive physical hydrogels. On the premise of adding chemical crosslinking agent, the pH sensitivity and mechanical strength of the obtained hydrogel are greatly improved

Method used

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  • Preparation method of physically-crosslinked chitosan-based hydrogel with efficient pH sensitivity and high mechanical strength
  • Preparation method of physically-crosslinked chitosan-based hydrogel with efficient pH sensitivity and high mechanical strength
  • Preparation method of physically-crosslinked chitosan-based hydrogel with efficient pH sensitivity and high mechanical strength

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Embodiment 1

[0035] The preparation of the physically cross-linked chitosan-based hydrogel with efficient pH sensitivity and high mechanical strength shown in embodiment 1. formula (I)

[0036] In step (1), at room temperature, 1.0 g of chitosan represented by formula (III) was dissolved in 10 mL of 1% acetic acid solution by mass fraction, and stirred overnight to prepare a transparent chitosan solution.

[0037] Step (2), add the monomer DMAEMA shown in the formula (II) and the monomer AAC shown in the formula (IV) (mass ratio is 2.5:97.5) into the round bottom flask, mix in 0 ℃ (ice-water bath) uniform.

[0038] Step (3), adding the potassium persulfate-sodium thiosulfate redox initiator with a mass concentration of 0.16% in the step (1) system, then adding the monomer mixture obtained in step (2), stirring evenly with a magnet and passing through Deoxygenate with nitrogen for 15 minutes.

[0039] In step (4), the reaction mixture prepared in step (3) is poured into a small test tube ...

Embodiment 2

[0043] Embodiment 2. As described in Example 1, the difference is that the quality of chitosan shown in the change formula (III) is 2g, the swelling ratio of the gel becomes 16.43, and the maximum compressive strength becomes 0.0326MPa.

Embodiment 3

[0044] Embodiment 3. As described in Example 1, the difference is that the mass ratio of monomer DMAEMA shown in changing formula (II) and monomer AAC shown in formula (IV) is 5:95, and the swelling rate of gel becomes 22.79, and the maximum compressive strength becomes 0.1309MPa.

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Abstract

A preparation method of physically-crosslinked chitosan-based hydrogel with efficient pH sensitivity and high mechanical strength, wherein the hydrogel is shown as the formula (I), belongs to the technical field of high-molecular functional modification synthesis of natural materials. The method comprises: taking hydroxy groups located on the surface of chitosan shown as the formula (III) as grafting sites; allowing potassium persulphate-sodium hyposulfite which is taken as a chemical initiator to be heated and decomposed to generate free radicals; on the active sites formed on chitosan, further triggering a part of monomers AAC shown as the formula (IV) and monomers DMAEMA shown as the formula (IV) to be grafted to main chains of chitosan through polymerization, while obtaining copolymermolecular chains of the two monomers, wherein the copolymer molecular chains are intermixed among macromolecular chains of chitosan grafted copolymer to form semi-interpenetrating network, thereby obtaining the hydrogel shown as the formula (I), and performing freeze drying to the hydrogel to obtain a solid product. The reaction is easy to operate, and the condition is mild. The physically-crosslinked hydrogel obtained from the preparation method is efficient in pH sensitivity, high in mechanical strength, good in biological compatibility and large in swelling rate, and has bright applicationprospects with the respect to macro-molecule solute separation, drug release systems, disease diagnosis and daily monitoring in the medical and medicine fields.

Description

technical field [0001] The invention relates to a preparation method of a physically cross-linked chitosan-based hydrogel with high-efficiency pH sensitivity and high mechanical strength, and belongs to the technical field of functional modification of natural polymer materials. Background technique [0002] Due to its unique responsiveness, smart hydrogels have broad application prospects in sensors, drug delivery, tissue engineering, and enzyme immobilization. , electric field, solvent properties, light intensity and light wavelength, pressure, ionic strength, etc.) The properties of the gel change accordingly, among which the pH-responsive hydrogel is the most important and most widely studied intelligent hydrogel Glue one. [0003] pH-sensitive hydrogels can change properties (such as swelling degree, shape, etc.) with the change of external pH value, and usually contain ionizable acidic or basic groups on the polymer chain of the gel, such as carboxyl, Sulfonic acid g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F251/00C08F220/06C08F220/34C08F2/10
Inventor 车玉菊孟凡君李冬平其他发明人请求不公开姓名
Owner SHANDONG UNIV
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