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Compound red sage root freezing-dried powder injection

A technology of freeze-dried powder injection and compound salvia miltiorrhiza, which is applied in the field of medicine, can solve the problems of slow onset of action, large dosage, and inconvenient carrying

Inactive Publication Date: 2011-10-26
TIANJIN TASLY ZHIJIAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing Chinese patent medicines are mainly decoctions and compound pills, which have the disadvantages of large dosage, inconvenient carrying, and slow onset of action.

Method used

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  • Compound red sage root freezing-dried powder injection
  • Compound red sage root freezing-dried powder injection
  • Compound red sage root freezing-dried powder injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0168] a. Take the prescription amount of Salvia miltiorrhiza 1000g, Panax notoginseng 850g and Borneol 5g for use;

[0169] b. The above Danshen and Panax notoginseng were extracted twice with water for 1 hour each time, and the extracts were combined and concentrated to obtain Danshen extract and Panax notoginseng extract; Borneol was dissolved with appropriate amount of ethanol and included with β-cyclodextrin;

[0170] Dissolve Danshen extract and Panax notoginseng extract with proper amount of water for injection, boil, let cool, filter, mix the filtrate with borneol β-CD inclusion solution, add mannitol, add proper amount of water for injection, adjust pH, and freeze-dry , That is.

[0171] In the above compound freeze-dried powder injection, the content of borneol is calculated as dextroborneol, and the content is determined by gas chromatography (Chinese Pharmacopoeia 2005 Edition One Appendix VI E).

[0172] Chromatographic conditions and system suitability test Chromatograph...

Embodiment 2

[0195] a. Take the prescription amount of Danshen 4000g, Panax notoginseng 260g, and Borneol 50g for use;

[0196] b. The above Danshen and Panax notoginseng are respectively extracted with ethanol to obtain Danshen extract and Panax notoginseng extract; Borneol is dissolved with proper amount of ethanol and clathrated with β-cyclodextrin;

[0197] Dissolve Danshen extract and Panax notoginseng extract with proper amount of water for injection, boil, let cool, filter, mix the filtrate with borneol β-CD inclusion solution, add mannitol, add proper amount of water for injection, adjust pH, and freeze-dry , That is.

[0198] The content was determined according to the method for determining the content of borneol in Example 1. This product contains borneol and dextroborneol (C 10 H 18 O), the content is 30.25-75.0mg / g freeze-dried powder solids.

[0199] The content was determined according to the method of determination of salvianolic acid B in Example 1. This product contains salvianol...

Embodiment 3

[0203] a. Take 1200g of Salvia miltiorrhiza, 300g of Panax notoginseng and 6g of borneol for use;

[0204] b. The above Danshen and Panax notoginseng were separately extracted with water, 3 times alcohol precipitation, combined and concentrated, to obtain Danshen extract and Panax notoginseng extract; Borneol was dissolved with appropriate amount of ethanol and included with β-cyclodextrin;

[0205] Dissolve Danshen extract and Panax notoginseng extract with proper amount of water for injection, boil, let cool, filter, mix the filtrate with borneol β-CD inclusion solution, add mannitol, add proper amount of water for injection, adjust pH, and freeze-dry , Make 1000 bottles, and get it.

[0206] The content was determined according to the method in Example 1. This product contains notoginseng and ginsenoside Rg1(C 27 H 32 O 16 ), based on the total amount of ginsenoside Rb1 and notoginsenoside R1, the content is 11.5-24.2 mg / g freeze-dried powder solids.

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Abstract

The present invention provides a compound red sage root freeze dried powder injection which comprises root of red rooted saliva, notoginseng, baras camphor through extracting root of red rooted saliva, notoginseng to obtain red sage root extract, pseudo-ginseng extract, finally dissolving baras camphor with right amount of ethanol. Calculated by the total amount of ginseng saponin Rg1 (C27H32O16), ginseng saponin Rb1, the content of notoginseng saponin R1 is 12.5-50.0mg / g of freeze-dried powder solid. Calculated by Danshensu (C9H10O5), the content of notoginseng is 2.5-15.5mg / g freeze-dried powder solid. Calculated by salvianolic acid B (C36H30O16), the content of salvia miltiorrhizae is 12.5-75.0mg / g of freeze-dried powder solid. Calculated by D-borneol (C10H180), the content of baras camphor is12.5-62.5mg / g of freeze-dried powder solid.

Description

Technical field [0001] The invention belongs to the field of medicine, and more specifically, relates to a compound Danshen freeze-dried powder injection prepared by using traditional Chinese medicine as a raw material. Background technique [0002] In most Western countries, cardiovascular deaths account for about half of the total deaths, of which coronary heart disease is the first, accounting for more than 50% of cardiovascular deaths. As an Asian country, coronary heart disease is less common in China than in European and American countries, but it has been on the increase in recent years. According to the vital statistics released by the Ministry of Health, in 1957 the deaths of urban residents from cardiovascular and cerebrovascular diseases accounted for 12.0% of the total, which rose to 16.6% in 1989, and the cause of death rose from 5th and 7th to 2nd and 3rd. It can be seen that the incidence of coronary heart disease is increasing year by year, and the cardiovascular...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K36/537A61K31/704A61P9/10A61K31/045
Inventor 叶正良李永强郑永锋周桂荣
Owner TIANJIN TASLY ZHIJIAO PHARMA