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Method for preparing larva powder of domestic silkworm with high content of 1 - deoxidized nojirimycin

A technology of deoxynojirimycin and silkworm, which is applied in powder delivery, metabolic diseases, animal husbandry, etc., can solve problems such as not being able to meet high-level demands, and achieve significant hypoglycemic effects, positive social and economic benefits, and high content Effect

Inactive Publication Date: 2007-12-26
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are multiple (4) chiral centers in the DNJ molecule, and there are as many as 15 or more stereoisomers related to it, and its derivatives synthesized by artificial chemistry are quite different from natural DNJ in terms of pharmacological effects and toxic and side effects. Differences, unable to meet the high-level needs of today's society

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] In spring, use ripe mulberry leaves at 25-28°C (27-28°C for the 1st-2nd age, 26°C for the 3rd-4th age, 25°C for the 5th age) to raise silkworms of the 54A×Feng1 variety until the 5th age. On the third day, the silkworms were starved for 22 hours at a low temperature of 18°C, and then moved into a refrigerator, and the temperature was gradually lowered to -30°C within 2 hours for freezing. The frozen silkworm was vacuum-dried at -50°C for 36 hours, then ultrafinely pulverized at -15°C for 10 minutes, and passed through a 300-mesh sieve to obtain light green silkworm larvae powder. The content of DNJ in silkworm larvae powder is 0.62%, which can significantly reduce the blood sugar level of alloxan-induced diabetic model mice, and its hypoglycemic effect reaches 41.6% after 10 days of administration. 10 batches of experiments all obtained the same results.

Embodiment 2

[0016] In spring, use ripe mulberry leaves at 25-28°C (27-28°C for the 1st-2nd age, 26°C for the 3rd-4th age, 25°C for the 5th age) to raise silkworms of the 54A×Feng1 variety until the 5th age. On the third day, the silkworms were starved for 20 hours at a low temperature of 20°C, and then moved into a refrigerator, and the temperature was gradually lowered to -30°C within 4 hours for freezing. The frozen silkworm was vacuum-dried at -50°C for 36 hours, then ultrafinely pulverized at -15°C for 15 minutes, and passed through a 400-mesh sieve to obtain light green silkworm larvae powder. The content of DNJ in silkworm larvae powder is 0.61%, which can significantly reduce the blood sugar level of alloxan-induced diabetic model mice, and its hypoglycemic effect reaches 42.8% after 10 days of administration. The same results were obtained for 8 batches of experiments.

Embodiment 3

[0018] In spring, use ripe mulberry leaves at 25-28°C (27-28°C for the 1st-2nd age, 26°C for the 3rd-4th age, 25°C for the 5th age) to raise silkworms of the 54A×Feng1 variety until the 5th age. On the third day, the silkworms were starved for 21 hours at a low temperature of 19°C, and then moved into a refrigerator, and the temperature was gradually lowered to -30°C within 3 hours for freezing. Frozen silkworms were vacuum-dried at -50°C for 36 h, then ultrafinely pulverized at -15°C for 10 min, and passed through a 300-mesh sieve to obtain light green silkworm larvae powder. The content of DNJ in silkworm larvae powder is 0.63%, which can significantly reduce the blood sugar level of alloxan-induced diabetic model mice, and its hypoglycemic effect reaches 41.0% after 10 days of administration. The same results were obtained for 9 batches of experiments.

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Abstract

The present invention discloses a domestic silkworm larva powder with high 1-deoxynojirimycin (DNj) content and its preparation method. Said domestic silkworm larva powder not only has high 1-deoxynojirimycin content, but also has the obvious effect for reducing blood sugar, so that it can be made into the medicine and health-care food for preventing and curing diabetes. Besides, said invention also provides the concrete steps of its preparation method.

Description

technical field [0001] The invention relates to a preparation method of silkworm larvae powder with high 1-deoxynojirimycin (DNJ) content. Background technique [0002] Diabetes mellitus is a common multiple chronic disease of endocrine and metabolic disorders, and its main clinical symptoms are hyperglycemia. With the improvement of social and economic conditions and the change of diet structure, the prevalence of diabetes has increased significantly in recent years, and it has become a serious public health problem in today's medicine, which has caused a great impact on the development of the national economy. At present, the drugs used clinically to treat diabetes mainly include insulins, sulfonylureas, biguanides and α-glucosidase inhibitors. Insulin, sulfonylureas and biguanides can cause liver damage, blood sugar Too low, edema, etc., side effects are relatively large, and α-glucosidase inhibitors are the key areas of current development. [0003] 1-deoxynojirimycin ...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K9/14A01K67/04A61P3/10
Inventor 时连根刘淑梅张作法金洁顾燕燕戚志良曾光远
Owner ZHEJIANG UNIV
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