Method of preparing maduramicin ammonium microemulsion
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A maduramycin ammonium and microemulsion technology, which is applied in the field of microemulsion preparations, can solve problems such as restricting wide application, and achieve the effects of prolonging residence time, good safety, and low manufacturing cost
Inactive Publication Date: 2008-02-27
杨水新
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Problems solved by technology
However, due to the insolubility of maduramycin ammonium itself in wate
Method used
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Example Embodiment
[0024] Example 1:
[0025] A maduramycin ammonium microemulsion is prepared by the following method:
[0026] (1). Take 1g of maduramycin ammonium, add 40ml of DMF, and stir well;
[0027] (2). Add 10ml of propylene glycol and stir evenly;
[0028] (3). Add Tween-803ml and stir evenly;
[0029] (4). Add 1ml of triethanolamine and stir evenly;
[0030] (5). Add water to 100ml and stir to form a maduramycin ammonium microemulsion solution.
Example Embodiment
[0031] Example 2:
[0032] A maduramycin ammonium microemulsion is prepared by the following method:
[0033] (1). Take 3g of maduramycin ammonium, add 30ml of DMF, and stir well;
[0034] (2). Add 10ml of propylene glycol and stir evenly;
[0035] (3). Add 5ml of Tween-80 and stir evenly;
[0036] (4). Add 5ml of triethanolamine and stir evenly;
[0037] (5). Add water to 100ml and stir to form a maduramycin ammonium microemulsion solution.
Example Embodiment
[0038] Example 3:
[0039] A maduramycin ammonium microemulsion is prepared by the following method:
[0040] (1). Take 5g of maduramycin ammonium, add 30ml DMF, and stir well;
[0041] (2). Add 25ml of propylene glycol and stir evenly;
[0042] (3). Add 5ml of Tween-80 and stir evenly;
[0043] (4). Add 2ml of triethanolamine and stir evenly;
[0044] (5). Add water to 100ml and stir to form a maduramycin ammonium microemulsion solution.
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PUM
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Abstract
The invention discloses a preparing method of actinomadura mycin amino microemulsion, which comprises the following steps: (1) fetching actinomadura mycin amino to add DMF; stirring evenly; (2) adding propylene glycol to stir evenly; (3) adding tween-80; stirring evenly; (4) adding triethanolamine to stir evenly; (5) adding water to stir; obtaining the product. The invention blends insoluble actinomadura mycin amino and water at random proportion to form the product with high biological utility and lengthen the retaining time in the body, which reduces the using quantity of drug to reduce cost and protect pollution, therefore fitting for treating kinds of disease initiated by coccidian to use conveniently.
Description
technical field [0001] The invention belongs to the field of microemulsion preparations, in particular to a preparation method of maduramycin ammonium microemulsion. Background technique [0002] Maduramycin ammonium is an anti-coccidiosis drug developed by the American Ammonium Cyanide Company. However, due to the insolubility of maduramycin ammonium itself in water, its wide application in veterinary medicine is seriously restricted. Contents of the invention [0003] The object of the present invention is to overcome the deficiencies in the prior art and provide a kind of preparation method of maduramycin ammonium microemulsion with good water solubility and long drug effect maintenance time. [0004] Realize the technical scheme of the present invention is: [0005] The concrete steps of a kind of preparation method of maduramycin ammonium microemulsion are: [0006] (1). Take 1 to 5 parts of maduramycin ammonium, add 20 to 50 parts of DMF, and stir evenly; [0007...
Claims
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Application Information
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