Unlock instant, AI-driven research and patent intelligence for your innovation.

Compositions for preventing and controlling climacteric syndrome and osteoporosis, and processes for producing the same

A composition and syndrome technology, applied in the field of medicine, can solve problems such as stimulating breast cells and increasing the incidence of breast cancer and endometrial cancer

Active Publication Date: 2008-02-27
酒泉大得利制药股份有限公司
View PDF0 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Estrogen replacement therapy (Hormone Replacement Therapy, HRT) is currently the main means of treatment of menopausal syndrome and osteoporosis, the curative effect is good, but the clinical results show that long-term use of estrogen replacement therapy will cause serious side effects, including uterine Bleeding, stimulate breast cells, endometrial hyperplasia, increase the incidence of breast cancer, endometrial cancer and other serious adverse reactions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compositions for preventing and controlling climacteric syndrome and osteoporosis, and processes for producing the same
  • Compositions for preventing and controlling climacteric syndrome and osteoporosis, and processes for producing the same
  • Compositions for preventing and controlling climacteric syndrome and osteoporosis, and processes for producing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Embodiment 1: the preparation of composition extract

[0060] [Prescription] Angelica 200g, Astragalus 1000g, Epimedium 1000g

[0061] [Preparation method] The above 3 flavors are crushed into coarse powder. Take angelica and astragalus, put them in a 20L extractor, add 16kg of water, stir and soak, heat and extract for 1 hour, filter while hot, and heat the residue with 8kg of water for 1 hour, filter while hot, and combine the filtrates. The filtrate is concentrated to a thick extract with a specific gravity of 1.05 to 1.1 to obtain extract I. Then take 1000g of epimedium coarse powder, put it in a 10L extractor, add 8L of 70% ethanol, heat and reflux for extraction for 1 hour after fully soaking, filter while hot, and heat and extract the residue with 6L of 70% ethanol for 1 hour, filter while hot, Combine the filtrates. The filtrate was collected under reduced pressure at 60°C and concentrated to a thick extract with a specific gravity of 1.05-1.1 to obtain extra...

Embodiment 2

[0062] Embodiment 2: the preparation of composition extract

[0063] [Prescription] Angelica 200g, Astragalus 1000g, Epimedium 1000g

[0064] [Preparation method] The above 3 flavors are crushed into coarse powder. Take angelica, astragalus, and epimedium, mix them evenly, put them in a 20L extractor, add 17.6kg of water, stir well, heat and extract for 1 hour, filter while hot, and reflow the residue with 11kg of water to extract for 1 hour, while Filtrate hot and combine the filtrates. The filtrate is concentrated into a thick extract with a specific gravity of 1.05 to 1.1, and the extract is taken and mixed thoroughly and then dried to obtain the extract 2 of the present invention.

Embodiment 3

[0065] Embodiment 3: the preparation of composition extract

[0066] [Prescription] Angelica 200g, Astragalus 1000g, Epimedium 1000g

[0067] [Preparation method] The above 3 flavors are crushed into coarse powder. Take angelica, astragalus, and epimedium, mix them evenly, put them in a 20L extractor, add 17.6kg of 70% ethanol, stir well, heat and reflux for extraction for 1 hour, filter while hot, and extract the residue with 11kg of ethanol under reflux After 1 hour, filter while hot, and combine the filtrates. The filtrate is recovered under reduced pressure and concentrated to a thick extract with a specific gravity of 1.05 to 1.1. The extract is taken and mixed thoroughly and then dried to obtain extract 3 of the present invention.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a medicinal composition for the prevention and treatment of climacteric metancholia and / or osteoporosis, and the process for preparing its extract, wherein the composition is prepared from Chinese angelica root, astragalus root and barren wort by a predetermined proportion through grilling and boiling. The composition can also be prepared from Chinese angelica root polysaccharide, astragalus root polysaccharides, ethanol extract of astragalus root and barren wort by a predetermined proportion. Tests show that, the composition or extract has good effects of estrogenic sampling, promoting bone cell proliferation and differentiation, thus can be further used for developing Chinese medicament for preventing and treating climacteric metancholia and osteoporosis.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular, the invention relates to a pharmaceutical composition, an extract and a preparation method thereof for preventing and treating menopausal syndrome and / or osteoporosis. Background technique [0002] Climacteric syndrome is a common disease with a high incidence rate and great harm. Among the menopausal population in my country, the incidence of menopausal neuropsychiatric symptoms is as high as 75.1%, reaching a peak before menopause, lasting about 7 years; the incidence of vasomotor dysfunction is 40.9%, peaking after the age of 50, and lasting for about 6 years. According to current research data, 99% of women may develop osteoporosis during and after menopause, also known as primary osteoporosis. It is a systemic skeletal disease characterized by decreased bone mass and degeneration of bone microstructure, resulting in increased bone fragility and susceptibility to fractures. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/481A61P15/12A61P19/10
Inventor 詹华强董婷霞
Owner 酒泉大得利制药股份有限公司