Method for producing Yujin composition and medicament containing the same

A composition and fish gold technology, applied in the field of medicine, can solve the problems of reducing clinical efficacy and high side effects

Inactive Publication Date: 2008-04-02
SHANDONG BUCHANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both of the above two patents made the extracted components into injections, which only reflected part of the curative effects of Houttuynia cordata and honeysuckle, reduced their clinical efficacy, and had high side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, the preparation of Houttuynia cordata, honeysuckle oral liquid

[0031] 1.1 Extraction of Houttuynia cordata and honeysuckle

[0032] Take 600g of Houttuynia cordata and 300g of honeysuckle flower, cut the above two flavors, Houttuynia cordata into 2-3cm small pieces, mix with honeysuckle, add 8 times the amount of hydrochloric acid acid water (pH value 2.4) to soak for 1 hour, and steam distill it to obtain First distillate 1000ml, collect distillate 500ml, carry out redistillation again, obtain the double distillate containing volatile components 250ml, keep in another container.

[0033] Filter the medicinal solution, concentrate the filtrate to a relative density of 1.13 (measured at 50° C.), and obtain a concentrated solution of water-soluble components for subsequent use; add 6 times of 75% ethanol (adjust the pH value with hydrochloric acid to 3.6) to the medicinal residue and reflux for 1 hour, filter, Combine with concentrate and let stand overni...

Embodiment 2

[0036] Embodiment 2, preparation of Houttuynia cordata, honeysuckle sheet

[0037] 2.1 Extraction of Houttuynia cordata and honeysuckle

[0038] Take 500g of Houttuynia cordata and 300g of honeysuckle flower, cut the above two flavors, Houttuynia cordata into small pieces of 2-3cm, mix with honeysuckle, add 6 times the amount of hydrochloric acid acid water (pH value is 4) and soak for 45min, steam distillation to obtain First distillate 1000ml, collect distillate 500ml, carry out redistillation again, obtain the double distillate containing volatile components 250ml, keep in another container.

[0039] Filter the medicinal liquid, concentrate the filtrate to a relative density of 1.10 (measured at 50° C.) to obtain a concentrated solution of water-soluble components, and set aside; add 8 times of 75% ethanol (adjust the pH value with hydrochloric acid to 3.2) to reflux for 75 minutes, filter, and The concentrates of water-soluble components were combined and allowed to stand...

Embodiment 3

[0053] The pharmacodynamics test of embodiment 3 Houttuynia cordata, honeysuckle (fish gold) oral liquid

[0054] 1. Experimental materials

[0055] 1.1 Drug Yujin Oral Liquid contains 0.9g of crude drug per 1ml, provided by the preparation room of Xi'an Xintong Pharmaceutical Co., Ltd.;

[0056] Positive control drug: ribavirin, injection, content 100mg / ml produced by Henan Xinxiang Pharmaceutical Factory, 1.2 virus and cell influenza virus FM 1 The strain was provided by the Institute of Virology, Chinese Academy of Preventive Medicine, passaged from the allantoic cavity of chicken embryos, and the titer was determined by hemagglutination. HEP-2 (Cincinnati strain) cells were provided by the Shanghai Cell Institute of the Chinese Academy of Sciences.

[0057] 1.3 Animals and Chicken Embryos Kunming mice 10-16g, chicken embryos 9-10 months old, all provided by the Experimental Animal Center of Xi'an Jiaotong University School of Medicine.

[0058] (1) Toxic effect of Yujin...

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PUM

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Abstract

The invention relates to an oral preparation of a drug combination of heartleaf houttuynia and honeysuckle, including the volatile component, the water soluble component and the spirit soluble component of the heartleaf houttuynia and the honeysuckle. The drug of the invention is mainly used for the symptoms of the upper respiratory infection, the bronchial pneumonia, the acute epidemic type-B encephalitis, the viral infection, the gynecological inflammation, the fever after the operation etc. The invention also relates to the extraction method of the main components which contain the drug combination and the preparation method of the drug preparation. The drug nature test indicates that compared with the market injection preparation, the drug of the invention has the advantages of good curative effect, low side effect, convenient use, cheap price etc.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a preparation of fish gold composition containing fish gold volatile components, water-soluble components and alcohol-soluble components and corresponding preparations. Background technique [0002] Houttuynia cordata is the whole herb of Houttuynida cordata thunb, a plant of the family Triaceae. It is pungent in taste and cool in nature. Houttuynia cordata contains 0.05% volatile oil, and its main components are decanoyl acetaldehyde (decanoyl acetaldenyde), myrcene, α-pinene, d-limonene (d-limonene), undecanone-2 (i.e. methyl nonanone) (2-undecanone), and camphene (camphene), bornyl acetate (bomylacetate), linalool (linalool), caryophyllene ( caryophyllene), dodecanaldehyde, etc. It also contains cordarine; flowers and ears contain isoquercitrin; leaves contain quercetin and inorganic components potassium chloride and potassium sulfate. The active ingredient decanoyl acetaldehyde of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K47/34A61K47/38A61K47/40A61P31/04A61P31/12A61K47/10A61K47/26A61K47/36
Inventor 张建林
Owner SHANDONG BUCHANG PHARMA
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