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Pharmaceutical combination with resisting liver cancer activity

A composition and anti-liver cancer technology, applied in the direction of drug combination, antineoplastic drugs, medical preparations containing active ingredients, etc., can solve the problems of incomplete medication, low cure rate, high cost, etc., and achieve high curative effect and safety , significant effect

Inactive Publication Date: 2008-05-21
谢岩
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Western medicine mainly uses chemotherapy in addition to surgery in the treatment of liver cancer. Chemotherapy often kills a large number of cancer cells and normal cells on the one hand, and quickly supplements high nutrition on the other hand, so that the cells of the patient's body are always in extreme fatigue. Although the body can be significantly reduced in a short period of time, it will recur soon
However, the traditional Chinese medicine treatment methods and drugs for tumors also have problems such as incomplete medication, unstable curative effect and low cure rate.
[0003] CN 1059800C discloses an injection containing ginseng and astragalus components, which is used to improve the immune function of the human body and has a certain effect on inhibiting tumor occurrence, but it has at least three problems: one is that the amount of toxic medicinal materials used to form the drug is relatively large; Therefore, the side effects are also relatively large, which affects the therapeutic effect; the second is that the dosage form is too single, and for patients, only the injection preparation is obviously difficult to meet the needs of both doctors and patients, and the administration is inconvenient; the third is that the production process is relatively backward, especially the extraction and refining The unqualified process seriously affects the quality of the injection. At the same time, the injection process is complicated and the cost is high
However, mylabris is still used in the raw materials of traditional Chinese medicine, and its toxic and side effects are still relatively large, especially irritating to the blood vessel wall and urinary tract, causing pain

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] Extract 800 g slices of ginseng with 8 times the amount of 75% ethanol under reflux for 3 times, combine the extracts, filter, recover the ethanol from the filtrate, concentrate it into a clear ointment with a relative density of 1.0-1.2 for later use; decoct the dregs with 8 times the amount of water for 3 The second time, combine the decoction, filter, concentrate the filtrate into a clear paste of 1.10-1.25, add ethanol up to 75%, let it stand, filter to collect the precipitate, and dry it at low temperature for later use. Slice 2000g of Radix Astragali, decoct 3 times with water, combine the decoction, filter, concentrate the filtrate and precipitate with ethanol, recover the ethanol from the filtrate and concentrate it into a clear paste equivalent to 5-8g of medicinal materials per 1ml for later use; the filtered precipitate is vacuum-dried spare. 4 g of toad venom is finely powdered, soaked in 25 times ethanol overnight, then refluxed for 4 hours, filtered, and t...

Embodiment 2

[0105] 4000g slices of ginseng were reflux extracted with 8 times the amount of 75% ethanol for 3 times, the extracts were combined, filtered, the filtrate recovered ethanol, concentrated into a clear paste with a relative density of 1.0-1.2 for later use; the dregs were decocted with 8 times the amount of water for 3 The second time, combine the decoction, filter, concentrate the filtrate into a clear paste of 1.10-1.25, add ethanol up to 75%, let it stand, filter to collect the precipitate, and dry it at low temperature for later use. Cut 8000g of Astragalus membranaceus into slices, decoct 3 times with water, combine the decoction, filter, concentrate the filtrate and precipitate with ethanol, recover the ethanol from the filtrate and concentrate it into a clear paste equivalent to 5-8g of medicinal materials per 1ml for later use; the filtered precipitate is vacuum-dried spare. 12g of toad venom is finely powdered, soaked in 25 times ethanol overnight, then refluxed for 4 ...

Embodiment 3

[0107]Use 8 times the amount of 75% ethanol to reflux extract 1000g of ginseng for 3 times, combine the extracts, filter, recover the ethanol from the filtrate, concentrate it into a clear ointment with a relative density of 1.0-1.2 for later use; decoct the dregs with 8 times the amount of water for 3 The second time, combine the decoction, filter, concentrate the filtrate into a clear paste of 1.10-1.25, add ethanol up to 75%, let it stand, filter to collect the precipitate, and dry it at low temperature for later use. Slice 3000g of Astragalus membranaceus, add water and decoct 3 times, combine the decoction, filter, concentrate the filtrate and precipitate with ethanol, recover the ethanol from the filtrate and concentrate it into a clear paste equivalent to 5-8g of medicinal materials per 1ml for later use; the filtered precipitate is vacuum-dried spare. 4 g of toad venom is finely powdered, soaked in 25 times ethanol overnight, then refluxed for 4 hours, filtered, and th...

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PUM

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Abstract

The invention relates to a drug combination with anti-hepatoma activity, and a preparation method and application thereof. The active ingredient of the drug combination is extracted from Panax, astragalus root, Toad Venom and Norcantharidin.

Description

technical field [0001] The invention relates to a pharmaceutical composition with anti-liver cancer activity and its preparation method and application. The active ingredients are from ginseng, astragalus, bufo bufo and norcantharidin. Background technique [0002] Cancer is a common and frequently-occurring disease that seriously endangers people's life, health and life. In recent years, about 1.6 million people die of cancer every year in my country, and liver cancer ranks first in the number of cancer deaths in China. As there are currently 120 million HBV carriers in our country, the treatment of liver cancer, especially the relief of the suffering of advanced cancer patients, the prolongation of their survival and the improvement of their quality of life, are all urgent research topics in this field. At present, Western medicine mainly uses chemotherapy in addition to surgery in the treatment of liver cancer. Chemotherapy often kills cancer cells and normal cells in la...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P1/16A61P35/00A61K31/365A61K35/56A61K35/65
Inventor 谢岩
Owner 谢岩
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