Antipyrotic

A technology of anti-inflammatory agent, licorice extract, applied in the field of anti-inflammatory agent for skin external use

Inactive Publication Date: 2008-06-11
MARUZEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, it is not yet known that oil-soluble licorice extract has at least one of the effects of hyaluronidase inhibitory activity, hexosaminidase release inhibition, platelet ag

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0052] -Preparation of oil-soluble licorice extract-

[0053] Add 10 liters of absolute ethanol to the root of 1 kg of Glycyrrhiza glabra, and extract by reflux for 5 hours. The obtained extract was concentrated under reduced pressure. Add 1 liter of ethyl acetate to the concentrated extract, reflux extraction for 5 hours, dry under reduced pressure, and pulverize to obtain 10 g of oil-soluble licorice extract.

[0054] The weight content of flavonoids in the oil-soluble licorice extract obtained in Preparation Example 1 was quantitatively measured by high pressure liquid chromatography (manufactured by JASCO Corporation), and the measurement result was: the content of glabridin was 20%.

preparation Embodiment 2

[0056] -Preparation of oil-soluble licorice extract-

[0057] Add 10 liters of absolute ethanol to the root of 1 kg of Glycyrrhiza glabra, and extract by reflux for 5 hours. The obtained extract was concentrated under reduced pressure, 1 liter of ethyl acetate was added to the concentrated extract, and the extract was refluxed for 5 hours. Purified with a synthetic adsorbent, dried under reduced pressure and then pulverized to obtain 5 g of oil-soluble licorice extract.

[0058] The weight content of flavonoids in the oil-soluble licorice extract obtained in Preparation Example 2 was quantitatively determined by high pressure liquid chromatography (manufactured by JASCO Corporation), and the measurement result was: the content of glabridin was 40%.

preparation Embodiment 3

[0060] -Preparation of oil-soluble licorice extract-

[0061] Add 10 liters of absolute ethanol to the root of 1 kg of Glycyrrhiza inflata, and extract by reflux for 5 hours. The obtained extract was concentrated under reduced pressure. 1 liter of ethyl acetate was added to the concentrated extract, and the extract was refluxed for 5 hours. The obtained extract was then concentrated under reduced pressure. Add 1 liter of ethyl acetic acid to the concentrated solution, reflux extraction for 5 hours, dry under reduced pressure and then pulverize to obtain 30 g of oil-soluble licorice extract.

[0062] The weight content of flavonoids in the oil-soluble licorice extract obtained in Preparation Example 2 was quantitatively measured by high pressure liquid chromatography (manufactured by JASCO Corporation), and the measurement result was: the content of licochalcone A was 20%.

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Abstract

An anti-inflammatory agent which comprises an oil-soluble licorice extract obtained by extraction treatment of either a leguminous plant of the genus Glycyrrhiza or a water extract of a leguminous plant of the genus Glycyrrhiza with an organic solvent, and has at least one effect selected from an inhibitory effect on hyaluronidase activity, an inhibitory effect on hexosaminidase release (i.e., an inhibitory effect on histamine release), an inhibitory effect on platelet aggregation and an inhibitory effect on phospholipase A2 activity.

Description

technical field [0001] The invention relates to an anti-inflammatory agent containing oil-soluble licorice extract, which has the functions of inhibiting hyaluronidase activity, inhibiting hexosaminidase release, inhibiting platelet aggregation and inhibiting phospholipase A 2 activity, and is particularly suitable as an anti-inflammatory agent for external application to the skin. Background technique [0002] Licorice has been known as a herbal medicine since ancient times, and it is currently mainly used as a raw material for edible sweeteners, pharmaceuticals, quasi-drugs, and the like. Among them, glycyrrhizin and glycyrrhetinic acid in the aqueous extract of licorice have good pharmacological effects such as anti-inflammatory, anti-ulcer and anti-allergy, and are widely used in the fields of food, medicine and cosmetics. [0003] On the other hand, it is well known that oil-soluble licorice extracts extracted from licorice using organic solvents such as ethanol and et...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61K8/97A61K31/122A61K31/352A61P7/02A61P17/00A61P29/00A61P43/00A61Q19/00
CPCA61K36/484A61K31/122A61P7/02A61P17/00A61P29/00A61P43/00
Inventor 三宅康夫伊藤洋子
Owner MARUZEN PHARMA
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