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Treatment of esophageal high grade dysplasia using photodynamic therapy

A highly dysplasia and dysplasia technology, applied in phototherapy, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve problems such as damage to surrounding normal tissue, and achieve the effect of less side effects and effective treatment

Inactive Publication Date: 2008-07-16
HEALTH RES INC
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Problems solved by technology

Unfortunately, treatment also causes significant damage to surrounding normal tissue

Method used

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  • Treatment of esophageal high grade dysplasia using photodynamic therapy

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Embodiment Construction

[0021] HPPH injections are preferably accomplished by the intravenous route in a physiologically compatible medium, usually over a period of 0.75 to 3 hours. This time is functionally dependent on the desired infusion rate and dose level. The concentration in the medium is preferably 0.5-1.5 mg / mL, and the medium is preferably a physiological saline solution of 0.1% polysorbate 80, 2% ethanol and 5% glucose.

[0022] Irradiation is accomplished using an optical fiber carrying laser light emitted by a laser. The laser may be any laser that emits light at a desired wavelength and energy, such as a dye laser or a diode laser. Exposure can be adjusted by adjusting the length of exposure and / or adjusting light intensity.

[0023] Phase I / II trials using HPPH and PHOTOFRIN using the above parameters TM A phase III trial was conducted, the latter approved by the US Food and Drug Administration, with the following response results for high-grade dysplasia, where CR was defined as c...

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Abstract

A method for treatment of esophageal high grade dysplasia comprising the steps of: injecting HPPH in a physiologically compatible medium into a patient having high grade dysplasia tissue to provide a dose level of 3 through 5 mg / m<2> of body surface area, waiting for a time period of 24 through 60 hours to permit preferential absorption of the HPPH into esophageal cancer tissue, and exposing the esophageal cancer tissue to light at a wavelength of about 670 +- 5 nm at an energy of from about 75 to about 200 Joules / cm.

Description

[0001] Cross references to related patent applications [0002] This application claims priority to US Provisional Application 60 / 879,435, filed January 9,2007. [0003] Statement Regarding Federally Funded Research [0004] This invention was made with support from the National Institute of Health under grant numbers NIH (1R21 CA109914-01 and CA 55792). The US Government has certain rights in this invention. Background of the invention [0005] High-grade dysplasia, often associated with Barrett's esophagus, is considered a marker of a substantially increased risk of developing esophageal cancer (Overholt et al., Gastrointestinal Endoscopy, volume 62, 488-498, 2005) . Patients with Barrett's esophagus and associated high-grade dysplasia have a greater than 50% increased risk of developing esophageal cancer, requiring aggressive treatment, such as high-risk surgery. Esophageal cancer is a debilitating and often fatal cancer that causes irritation, pain, difficulty swallowi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/407A61P35/00A61P1/00A61N5/06
CPCA61K31/409A61P1/00A61P1/04A61P35/00A61K31/7004
Inventor 托马斯·J·多尔蒂拉温德拉·K·潘迪戴维·A·贝尔涅赫克托·R·纳瓦
Owner HEALTH RES INC
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