Nimodipine pulse sustained release mircopill preparation and preparing method thereof

Abstract

The invention relates to a pulsed sustained-release pellet comprising nimodipine and a preparation method is also provided. The sustained-release pellet comprises: one of gastric-dissolved and medicines containing sustained-release pellets and enteric-coated and medicines containing sustained-release pellets, or the combination. The preparation method is that: making medicines containing pellets using nimodipine and excipents, coating the medicines containing pellets with the gastric coating or the enteric coating, mixing the sustained-release pellets coated with gastric coating and enteric coating in proportion and putting the sustained-release pellets into capsules or tabletting. The pulsed sustained-release pellet of the invention has a special release behavior and needs to be taken only once per day. The release curve agrees well with the disease circadian rhythm of cerebrovascular disease patients, playing a role of the best prevention and treatment.

Description

Nimodipine pulse sustained-release pellet preparation and preparation method thereof technical field The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation method of pulse sustained-release pellets containing nimodipine. technical background Nimodipine is a dihydropyridine calcium ion antagonist, which is highly selective for brain tissue receptors and easily penetrates the blood-brain barrier. By effectively preventing calcium ions from entering cells and inhibiting smooth muscle contraction, the purpose of releasing vascular smooth muscle is achieved, thereby protecting brain neurons, stabilizing their function, increasing cerebral blood perfusion, improving cerebral blood supply, and increasing tolerance to hypoxia. At present, it is widely used in cerebrovascular disease and nootropic drugs in clinical practice. The main indications are: (1) prevention and treatment of subarachnoid hemorrhage and cerebral vasospasm; ...

AI Technical Summary

Problems solved by technology

However, due to the large daily dosage of nimodipine, which is almost insoluble in water, and the particularity of other physical and chemical properties, the release rate of the drug is difficult to control, and it is difficult to make a pulse sustained-release preparation that is administered once a day and has time characteristics.

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