Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Thymus gland pentapeptide injection and uses thereof

An injection and thymus technology, which is applied in the field of medicine, can solve the problems of patients with storage conditions using denatured and ineffective medicines, and achieve the effects of eliminating the possibility of infection, solving stability problems, and reducing energy consumption and costs.

Active Publication Date: 2008-08-20
CHENGDU DIAO JIUHONG PHARMA FACTORY
View PDF3 Cites 27 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Drugs that require low-temperature storage have strict requirements on drug logistics and storage conditions, and require additional temperature-controlled equipment and special storage locations. Hidden dangers of using denatured and invalid drugs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Thymus gland pentapeptide injection and uses thereof
  • Thymus gland pentapeptide injection and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The preparation of embodiment 1 Thymopentin injection of the present invention

[0042] (1) Prescription (dosage per 1000 bottles of injection, specification: 1ml: 1mg thymopentin)

[0043] Thymopentin 1.0g

[0044] Mannitol 40.0g

[0045] Sodium metabisulfite 2.0g

[0046] Acetic acid and sodium acetate (3:4) 5.0g

[0047] Appropriate amount of water for injection

[0048] Full volume 1000ml

[0049] (2) Accurately weigh thymopentin and each auxiliary material respectively by prescription quantity;

[0050] (3) Add thymopentin, mannitol and sodium metabisulfite of the prescription amount into about 950ml water for injection respectively, and stir until completely dissolved;

[0051] (4) measure the pH value, adjust the pH value to 5.0 with acetic acid and sodium acetate;

[0052] (5) Supplement water for injection to 1000ml;

[0053] (6) remove the pyrogen by ultrafiltration column, and then filter and sterilize with a filter sterilized by high pressure steam;...

Embodiment 2

[0056] The preparation of embodiment 2 Thymopentin injection of the present invention

[0057] (1) Prescription (dosage per 1000 bottles of injection, specification: 1ml: 10mg)

[0058] Thymopentin 10.0g

[0059] Mannitol 75.0g

[0060] Sodium metabisulfite 2.0g

[0061] Acetic acid and sodium acetate (3:4) 5.0g

[0062] Appropriate amount of water for injection

[0063] Full volume 1000ml

[0064] (2) Accurately weigh thymopentin and each auxiliary material respectively by prescription quantity;

[0065] (3) Add thymopentin, mannitol and sodium metabisulfite of the prescription amount into about 950ml water for injection respectively, and stir until completely dissolved;

[0066] (4) measure the pH value, adjust the pH value to 6.0 with acetic acid and sodium acetate;

[0067] (5) Supplement water for injection to 1000ml;

[0068] (6) remove the pyrogen by ultrafiltration column, and then filter and sterilize with a filter sterilized by high pressure steam;

[0069...

Embodiment 3

[0071] The preparation of embodiment 3 Thymopentin injection of the present invention

[0072] (1) Prescription (dosage per 1000 bottles of injection, specification: 1ml: 5mg)

[0073] Thymopentin 5.0g

[0074] Mannitol 60.0g

[0075] Sodium metabisulfite 3.0g

[0076] Acetic acid and sodium acetate (3:7) 8.0g

[0077] Appropriate amount of water for injection

[0078] Full volume 1000ml

[0079] (2) Accurately weigh thymopentin and each auxiliary material respectively by prescription quantity;

[0080] (3) Add thymopentin, mannitol and sodium metabisulfite of the prescription amount into about 950ml water for injection respectively, and stir until completely dissolved;

[0081] (4) measure the pH value, adjust the pH value to 6.0 with acetic acid and sodium acetate;

[0082] (5) Supplement water for injection to 1000ml;

[0083] (6) remove the pyrogen by ultrafiltration column, and then filter and sterilize with a filter sterilized by high pressure steam;

[0084] (...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a thymopentin injection, comprising a thymopentin as an active component, a plurality of accessories for injection, and certain amount of sterile water for injection, wherein the accessories for injection comprises protective agent, antioxidant and pH regulator. The dosage is as follows: point one to two hundred mg / ml thymopentin, ten to two hundred mg / ml protective agent, point one to ten mg / ml antioxidant, and point five to twenty mg / ml pH regulator. The injection has the advantages of stability while refrigerated at the temperature between two to ten degrees centigrade and long periods of preservation; the purity of the thymopentine remains ninety-nine percent after being stored for twenty-four months; the injection can be stored for six months to twelve months at normal temperature, which significantly facilitates circulation and transportation of drugs, thus ensures excellent stability of the injection.

Description

technical field [0001] The invention relates to a thymopentin injection, which belongs to the field of medicines. Background technique [0002] Thymus is the primary lymphoid epithelial tissue, the central immune organ of the body, and the central organ of T-cell development. In addition to providing a microenvironment required for T-cell development, it can also produce a variety of thymosin hormones. Thymus hormone can induce the differentiation and maturation of various T-cell subsets, and can also enhance the response performance of various T-cells, thereby regulating the function of the entire immune system. Animal thymus (including humans) gradually shrinks and degenerates with age after adulthood, and the secretion of thymus hormones also gradually decreases, and it shrinks significantly in old age, with only a small amount of cortex and medulla remaining. Therefore, some people think that senile infectious diseases, tumors, A high incidence of autoimmune disease is ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/08A61K9/08A61K47/10A61K47/12A61K47/02A61K47/18A61K47/22A61P35/00A61P37/02
Inventor 叶兵武勇李伯刚刘忠荣及元乔黄沛
Owner CHENGDU DIAO JIUHONG PHARMA FACTORY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com