Diastatin nystatin menthol combination with cooperating knife-bar

A composition and a technology of sterilizing mycin, which is applied in the direction of medical preparations containing active ingredients, drug combinations, active ingredients of hydroxyl compounds, etc., to achieve the effect of preventing fungal infection, preventing or treating fungal infection, and less irritation

Inactive Publication Date: 2008-09-03
BEIJING CENTURY BIOCOM PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, it is mainly used for Candida infection of the oral cavity, gastrointestinal tract, vagina, and skin and mucous membranes, but it is ineffective for oral treatment of systemic fungal infections or deep fungal infections

Method used

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  • Diastatin nystatin menthol combination with cooperating knife-bar
  • Diastatin nystatin menthol combination with cooperating knife-bar
  • Diastatin nystatin menthol combination with cooperating knife-bar

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Nystatin 500,000 units

[0015] Menthol 20mg

[0016] Crystalline Cellulose 15mg

[0017] Lactose 87mg

[0018] Pregelatinized starch 20mg

[0019] Crospovidone 100mg

[0020] Micronized silica gel 1.7mg

[0021] Preparation:

[0022] Weigh the raw and auxiliary materials in the prescription one by one according to the proportion of the prescription, and mix them according to the method of equal addition. Measure the content of nystatin in the mixed material, adjust the weight of the tablet according to the test result of the semi-finished product, and press the tablet.

Embodiment 2

[0024] Nystatin 500,000 units

[0025] Menthol 1mg

[0026] Crystalline Cellulose 15mg

[0027] Lactose 20mg

[0028] Pregelatinized starch 20mg

[0029] Crospovidone 20mg

[0030] Micronized silica gel 1.7mg

[0031] Preparation:

[0032] Weigh the raw and auxiliary materials in the prescription one by one according to the proportion of the prescription, and mix them according to the method of equal addition. Measure the content of nystatin in the mixed material, adjust the weight of the tablet according to the test result of the semi-finished product, and press the tablet.

Embodiment 3

[0034] Nystatin 100,000 units

[0035] Menthol 3mg

[0036] Crystalline Cellulose 15mg

[0037] Mannitol 100mg

[0038] Pregelatinized starch 100mg

[0039] Crospovidone 150mg

[0040] Micronized silica gel 1.7mg

[0041] Preparation:

[0042] Weigh the raw and auxiliary materials in the prescription one by one according to the proportion of the prescription, and mix them according to the method of equal addition. Measure the content of nystatin in the mixed material, adjust the weight of the tablet according to the test result of the semi-finished product, and press the tablet.

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PUM

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Abstract

The invention relates to a pharmaceutical composition for synergetic treatment and prevention of fungal infections and a preparation method thereof. The composition comprises nysfungin and menthol with a weight ratio of (1-20):1 as active ingredients.

Description

technical field [0001] The present invention relates to a composition with synergistic effect of preventing or treating candida infection, in particular to a synergistic composition of nystatin and menthol with synergistic effect of preventing or treating candida infection . Background technique [0002] Nystatin (Fungicidin, Nysfafin, Nystatin) (about 100 mg per 500,000 unit weight) is a polyene antifungal antibiotic, which has a strong effect on most deep and superficial infection fungi, and has a strong effect on various fungi such as Candida albicans Bacteria, Cryptococcus, Capsular Histoplasma, Coccidioides, etc. have inhibitory effects. Nystatin has antibacterial and bactericidal effects. Its mechanism of action is mainly to change the permeability of the cell membrane, combine with the plasma membrane, remove potassium ions and other components in the cell, and inhibit its growth. It has a significant effect on Candida, such as gastrointestinal candidiasis, oral th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/047A61P1/02A61P31/02A61K47/08
Inventor 郝守祝
Owner BEIJING CENTURY BIOCOM PHARMA TECH
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