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Preparation of Chinese medicine oral preparation

A technology for oral preparations and traditional Chinese medicines, which is applied in the field of preparation of oral preparations, can solve the problems of immature technology and difficulty in preparing preparations, etc., and achieves the effects of reasonable and feasible technology, easy process operation and small clinical dosage.

Active Publication Date: 2008-09-17
SICHUAN SUNNYHOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this patent only introduces the preparation process of individual dosage forms, and the process is not mature enough, so it is difficult for those of ordinary skill in the field of pharmacy to make qualified various preparations

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0025] Embodiment 1: the preparation of pharmaceutical composition capsule of the present invention

[0026] Take Phellodendron 260g, Gentiana chinensis 340g, Corydalis Corydalis 250g. The above 3 medicinal materials, Corydalis Corydalis is crushed into fine powder; Corydalis Corydalis and the other 2 medicinal materials are soaked in water for 2 hours, decocted twice, the temperature is controlled at 95-100 °C, and the amount of water added for the first time is 6 times the weight of the raw material medicine. , decocted for 1.5 hours, added water for the second time to be 5 times the weight of the raw material drug, decocted for 1 hour, combined the decoction, filtered, and the filtrate was concentrated into an extract with a relative density of 1.20~1.25 (60°C thermal measurement). With corydalis powder as the base material and extract as binder, one-step granulation (atomization pressure 0.25Mpa, material temperature 65°C, inlet air temperature 100°C, outlet air temperatur...

Embodiment 2

[0027] Embodiment 2: the preparation of pharmaceutical composition capsule of the present invention

[0028] Take Phellodendron 260g, Gentiana 340g, Corydalis 255g, Alisma 260g, Smilax 145g, Radix Paeoniae Rubra 260g. The above 6 herbs, Smilax smilax and Alisma are crushed into fine powder; Smilax smilax, Alisma and other 4 herbs are soaked in water for 12 hours, decocted twice, the temperature is controlled at 85-100°C, the amount of water added for the first time 6 times the weight of the crude drug, decoct for 1.5 hours, add water for the second time to 5 times the weight of the crude drug, decoct for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.10-1.15 (60°C Heat test) extract, add ethanol to make the alcohol content reach 60%~70%, leave standstill, reclaim ethanol after filtering. Use Smilax smilax, Alisma powder and about 100g starch as the base material, use the extract as the binder, and granulate in one step (atomizat...

Embodiment 3

[0029] Embodiment 3: the preparation of pharmaceutical composition pill of the present invention

[0030] Take Phellodendron 255g, Gentiana 350g, Corydalis 260g, Semen Plantaginis 245g, Smilax 155g, and Achyranthes bidentata 250g. The above 6 medicinal materials, soil Poria cocos and Corydalis corydalis are crushed into fine powder; the remaining 5 medicinal materials are decocted twice, the temperature is controlled at 85-90 ℃, the amount of water added for the first time is 7 times the weight of the raw material medicine, and decocted for 2 hours , the amount of water added for the second time is 6 times the weight of the raw material drug, decocted for 1.5 hours, the amount of water added for the third time is 5 times the weight of the raw material drug, decocted for 1 hour, the decoction is combined, filtered, and the filtrate is placed in a three-effect concentrator The temperature of the first effect is 80~90°C, the second effect is 70~80°C, and the third effect is 60~70°C...

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Abstract

The invention relates to a preparation method for a traditional Chinese medicine oral preparation with traditional Chinese medicines as main materials. One, two or three raw medicines of the medicine composites are shattered and sifted out; the other non-shattering raw medicines are grouped or not grouped, decocted and extracted with water, concentrated and refined; the shattering and sifting rawmedicine powder is used as basic charge by added in one or two components of proper starch, dextrine and micro silica gel, and water extract is injected for a one-step granulation for troche, capsule, pill, granular formulation and other formulations. The invention has a feasible technology, decreases the impurity in the extract and the loss of the active ingredient in the extraction process, thegranulation is more convenient, the grain is more uniform, the subsequent working procedures of tabletting and enpsulation are easier; the prepared traditional Chinese medicine compound preparation for curing the gout disease has the advantages of high preparation quality, low clinical dose and other advantages; each index of the product is fully qualified, and the quality of the product is improved greatly.

Description

technical field [0001] The invention relates to a preparation method of an oral preparation, in particular to a preparation method of an oral preparation which uses traditional Chinese medicine as a raw material and can be used for treating gout. Background technique [0002] Gout is a group of heterogeneous diseases caused by an increase in blood uric acid concentration due to purine metabolism disorder, excessive uric acid production or / and decreased uric acid excretion in the body. Clinical features include characteristic acute arthritis, tophi, and interstitial nephritis caused by hyperuricemia and urate crystal deposition, and severe joint deformities and dysfunction. [0003] Traditional Chinese medicine believes that the cause of gout—hyperuricemia is the poison of dampness and turbidity. Gout is based on the deficiency of the spleen and kidney, and the main pathogenesis is the accumulation of dampness and turbidity. Spleen dysfunction, spleen and stomach ascending ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K36/884A61K36/896A61K36/71A61K36/68A61K36/66A61K36/51A61K47/36A61K47/24A61P19/06
Inventor 郭成辉吴聪梁灏
Owner SICHUAN SUNNYHOPE PHARM CO LTD
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