Medicament composition for curing diabetic cardiovascular pathological changes and method of preparing the same

A technology of diabetes and composition, applied in the field of composition for treating diabetic cardiovascular disease and its preparation field, can solve the problems of low purity of arctiside, unfavorable production quality control and improvement of drug effect, etc.

Inactive Publication Date: 2008-10-08
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] The disadvantages of the above inventions are: only the hypoglycemic effect of arctium extract is found; the medicinal ingredients

Method used

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  • Medicament composition for curing diabetic cardiovascular pathological changes and method of preparing the same
  • Medicament composition for curing diabetic cardiovascular pathological changes and method of preparing the same
  • Medicament composition for curing diabetic cardiovascular pathological changes and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0077] Example 1 Preparation method of arctiin and arctigenin

[0078] (1) Preparation of arctiin

[0079] ① Crude extraction of arctiin: After pulverizing the burdock seed, place it in a Soxhlet extractor and degrease it by refluxing petroleum ether at a boiling range of 60-90°C for 2 times. After degreasing, take it out and dry it, and extract it by refluxing with 60% 8 times ethanol for 2 times. 0.8h each time, the extract was concentrated under reduced pressure at 60°C to obtain a dark brown extract;

[0080] ②Refining of macroporous resin: add 15% ethanol to the dark brown extract, ultrasonically treat it for 15 minutes to make it just fully dissolve, filter and adjust to a solution with a concentration of about 5mg / mL, and pass it through the AB-8 type macroporous adsorption resin. The volume of the macroporous adsorption resin is 1 times the chemical solution, the flow rate is controlled to 1.5BV / h, the column diameter to height ratio is controlled to 1:5, the volume of the...

Example Embodiment

[0085] Example 2 Preparation method of arctiin and arctigenin

[0086] (1) Preparation of arctiin

[0087] ① Crude extraction of arctiin: After pulverizing the burdock seed, place it in a Soxhlet extractor and degrease it with petroleum ether at a boiling range of 60-90℃ for 4 times. After degreasing, take it out and dry it, and extract it with 80% 8 times ethanol under reflux for 4 times. Every 2h, the extract was concentrated under reduced pressure at 80°C to obtain a dark brown extract;

[0088] ②Refining of macroporous resin: add dark brown extract with 35% ethanol, ultrasonic treatment for 35 minutes to make it just fully dissolve, filter and adjust to a solution with a concentration of about 7mg / mL, pass it through AB-8 type macroporous adsorption resin, The volume of the macroporous adsorption resin is twice that of the chemical solution, the flow rate is controlled at 2.5BV / h, the column diameter-to-height ratio is controlled at 1:5, the volume of the resin is washed 3 tim...

Example Embodiment

[0093] Example 3 Preparation method of arctiin and arctigenin

[0094] (1) Preparation of arctiin

[0095] ① Crude extraction of arctiin: After pulverizing the burdock seed, place it in a Soxhlet extractor and degrease it by refluxing petroleum ether at a boiling range of 60-90℃ for 3 times. After degreasing, take it out and dry it, and extract it with 70% 8 times ethanol reflux for 3 times. For 1 hour each time, the extract was concentrated under reduced pressure at 70°C to obtain a dark brown extract;

[0096] ②Refining of macroporous resin: add 20% ethanol to the dark brown extract, ultrasonically treat it for 20 minutes to make it just fully dissolve, filter and adjust to a solution with a concentration of about 6mg / mL, and pass it through the AB-8 type macroporous adsorption resin. The volume of the macroporous adsorption resin is 1.5 times the volume of the chemical solution, the flow rate is controlled to 2BV / h, the column diameter to height ratio is controlled to 1:5, the ...

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Abstract

The invention relates to a composition containing arctiin or arctigenin and a preparation method thereof. The purity of the arctiin and the arctigenin is over 90 percent. The weight part of the arctiin is 50 to 99. The weight part of the arctigenin is 1 to 50. The invention has the function of treating and preventing diabetic cardiovascular. The arctiin or arctigenin is made pure to prepare the composition. The results of pharmacology, toxicology and clinical trial show that the arctiin or the arctigenin composition of the invention has the characteristic that the composition has good effect on treating diabetic retinopathy and little toxic and side effect.

Description

technical field [0001] The invention relates to a pharmaceutical composition with plant material extract as an active ingredient, in particular to a group of compositions for treating diabetic cardiovascular disease and a preparation method thereof. Background of the invention [0002] At present, the incidence of diabetes in the world is about 4.6%, with a total of 200 million people. Its incidence rate is increasing year by year. It is estimated that by 2025, the incidence rate of diabetes will be about 5.4%, reaching 300 million people. [0003] Diabetic cardiovascular complications are the most common and serious chronic complications of diabetic patients, such as atherosclerosis of large and medium arteries and microvascular lesions (diabetic nephropathy, diabetic retinopathy, and diabetic cerebrovascular dysfunction, etc.), which are the main causes of poor prognosis and leading cause of death. Diabetes can cause endothelial cell damage and insufficiency, leading to ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/365A61K36/28A61P3/10A61P9/00
Inventor 卢春来周世文张蓉徐梓辉黄林清邢茂应懿周吉银
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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