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Novel method for Racemizing sertraline isomer
A technology of racemization and sertraline, applied in the direction of organic chemistry, purification/separation of amino compounds, etc., can solve problems such as high pollution, and achieve the effects of low production cost, high content and mild reaction conditions
Inactive Publication Date: 2008-10-15
ZHEJIANG JINGXIN PHARMA
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The invention discloses a method for the racemization of sertraline isomer. The prior method has the disadvantages that the product recovery rate is low, the cost is high, different processing methods are adopted for different isomers, and the steps are complex. In the method, an organic solvent and a strong base are added into the sertraline isomer, racemization processing is performed after the sertraline isomer is heated to backflow, heat preservation is performed, distillation is performed to remove the solvent, water is added, the pH value of the solution is adjusted by acid, extraction is performed, and then the extract is dried by distillation to obtain the sertraline. The method can perform racemization processing to all sertraline isomers and can be completed in one process, the sertraline isomer is fully utilized, and the content of obtained sertraline is high.
Description
A New Method for the Racemization of Sertraline Isomers technical field The present invention relates to a process for the racemization of isomers of sertraline. Background technique Sertraline hydrochloride (hereinafter referred to as sertraline), the chemical name is (1S,4S)-4-(3,4-dichlorobenzene) 1,2,3,4-tetrahydro-N methyl-1-naphthalene Amine hydrochloride has the following formula structure. Sertraline is the latest one among selective serotonin reuptake inhibitors. It inhibits the reuptake of 5-HT in the presynaptic membrane, thereby increasing the 5 -HT concentration, to achieve antidepressant effect, used to treat depression, obsessive-compulsive disorder and phobia. The sertraline product prepared by the existing method contains the following three isomers, and there are also various racemization methods for converting the isomers into sertraline. Sertraline Isomer I Isomer II Isomer III US5082970 patent discloses the method of using potassium alkoxide or ...
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IPC IPC(8): C07C211/42C07C209/82
Inventor 金志平周立栋俞洪勇
Owner ZHEJIANG JINGXIN PHARMA
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