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Novel preparation method for donkey-hide gelatin hematonic and quality control method

A quality control method, the technology of donkey-hide gelatin enriching blood ointment, which is applied in blood diseases, capsule delivery, ointment delivery, etc., can solve the problems of long extraction process time, incomplete extraction of active ingredients of drugs, and lack of characteristic indicators in quality control methods

Active Publication Date: 2008-10-29
HENAN NEW SIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are problems that the percolation extraction process takes a long time, the active ingredients of the drug are not completely extracted, and the quality control method lacks characteristic indicators

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Prescription composition: Ejiao 150g Rehmannia glutinosa 300g Codonopsis 300g Astragalus 150g Lycium barbarum 150g Atractylodes macrocephala 150g.

[0038] Preparation method: Prescribe six medicinal materials, except donkey-hide gelatin, decoct Rehmannia glutinosa with 10 times the amount of water twice, each time for 2 hours, combine the decoction, filter, let stand, and take the supernatant for later use; the rest of Atractylodes macrocephala and medlar Add 8 times the amount of 60% ethanol, heat and reflux for extraction twice, 1.5 hours each time; add 8 times the amount of 25% ethanol for Codonopsis and Radix Astragali, heat and reflux for 2 times, each time 1.5 hours, filter, combine the filtrate, and let it stand , filter; add donkey-hide gelatin, rehmannia glutinosa supernatant and simple syrup, mix well, concentrate under reduced pressure to get 10g of this product, add 20ml of water to dilute, and measure according to law (Chinese Pharmacopoeia 2005 edition one...

Embodiment 2

[0039] Example 2: Prescription: Ejiao 150g Rehmannia glutinosa 300g Codonopsis 300g Astragalus 150g Lycium barbarum 150g Atractylodes macrocephala 150g.

[0040] Preparation method: Prescribe six medicinal materials, except donkey-hide gelatin, decoct Rehmannia glutinosa with 10 times the amount of water twice, each time for 2 hours, combine the decoction, filter, let stand, and take the supernatant for later use; the rest of Atractylodes macrocephala and medlar Add 8 times the amount of 60% ethanol, heat and reflux for extraction twice, 1.5 hours each time; add 8 times the amount of 25% ethanol for Codonopsis and Radix Astragali, heat and reflux for 2 times, each time 1.5 hours, filter, combine the filtrate, and let it stand , filtered; mixed with Rehmannia glutinosa supernatant, concentrated under reduced pressure to a relative density of 1.15-1.20 (70°C), spray-dried, and made into medicinal extract powder; take the prescribed amount of donkey-hide gelatin fine powder, starc...

Embodiment 3

[0041] Example 3: prescription: donkey-hide gelatin 150g Rehmannia glutinosa 300g Codonopsis 300g astragalus 150g medlar 150g Atractylodes macrocephala 150g.

[0042] Preparation method: Prescribe six kinds of medicinal materials, except donkey-hide gelatin made into fine powder, decoct Rehmannia glutinosa with 10 times water for 2 times, each time for 2 hours, combine the decoction, filter, stand still, take the supernatant for later use; the rest of Atractylodes macrocephala Add 8 times the amount of 60% ethanol to Lycium barbarum, heat and reflux for extraction twice, each time for 1.5 hours; add 8 times the amount of 25% ethanol for Codonopsis and Radix Astragali, heat and reflux for 2 times, each time for 1.5 hours, filter, and combine the liquid , stand still, filter, mix with the supernatant of rehmannia glutinosa, concentrate under reduced pressure to a thick paste with a relative density of 1.20-1.26, take donkey-hide gelatin powder, mix 100g of starch, put it in a boi...

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Abstract

The invention relates to a new preparation method of a donkey-hide glue paste for nourishing blood and a quality control method, the donkey-hide glue paste for nourishing blood pertains to the types of Chinese traditional patent medicines promulgated by ministry; donkey-hide glue, radix rehmanniae preparata, pilose Asiabell root, membranous milkvetch root, barbary wolfberry fruit and largehead atractylodes rhizome are taken as active ingredients, and the original preparation process has the problems of long time used for the extraction process by the percolation method, non-complete extraction of the active ingredients of the medicines and lack of characteristic indicators of the quality standards. The new preparation method of the invention aims at proposing a reasonable production process, improving the transfer rate of the active ingredients of the medicines, improving the production efficiency and the utilization rate of the medicines, further ensuring the efficacy and simultaneously proposing the quality control method with stronger relevance with the internal quality.

Description

technical field [0001] The invention relates to a preparation process and a quality control method of a medicine, in particular to a new preparation method and a quality control method of Ejiao Buxue Plaster. Background technique [0002] Donkey-hide gelatin enriching blood ointment belongs to the Chinese patent medicines recorded by the ministry. The prescription consists of donkey-hide gelatin, rehmannia glutinosa, Codonopsis pilosula, astragalus, medlar, and Atractylodes macrocephala as active ingredients. Decoction, filter, leave standstill, get the supernatant for subsequent use; use 60% ethanol for the remaining Atractylodes macrocephala and Lycium barbarum; use 25% ethanol for Codonopsis radix and Radix Astragali, according to the percolation method under the extract and extract (2005 edition Chinese Pharmacopoeia Part 10) percolate, combine the filtrate, stand still, and filter; add donkey-hide gelatin, rehmannia glutinosa supernatant and simple syrup, etc., mix well...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61K9/48A61K9/10A61K9/06A61K9/20A61K9/46G01N30/90G01N30/02A61P31/12A61P31/04A61P7/06A61K35/36
Inventor 杨景华
Owner HENAN NEW SIFANG PHARMA
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