Shorten human papilloma virus 16 type L1 protein
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- XIAMEN INNOVAX BIOTECH
- Publication Date
- 2008-10-29
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Abstract
Description
technical field The invention relates to a truncated human papillomavirus type 16 L1 protein, a virus-like particle composed of it, a vaccine containing the virus-like particle and its use in preventing cervical cancer. Background technique Human papillomavirus HPV (Human Papillomavirus) is a non-enveloped DNA virus belonging to the family Papovaviridae. The viral genome is a double-stranded closed circular DNA with a size of about 7.2-8 kb and 8 open frames. The genome can be divided into three regions according to different functions: ① early region (E), about 4.5kb, encoding E1, E2, E4-E76 non-structural proteins related to virus replication, transcription and transformation; ② late region (L ), about 2.5kb, encoding major capsid protein L1 and minor capsid protein L2; ③Long regulatory region (LCR), located between the end of the L region and the beginning of the E region, about 800-900bp long, does not encode any protein , containing DNA replication, expression control...