Applications of thymic peptide beta4 in preparing medicament for preventing and treating bronchial asthma

Abstract

The invention provides the application of thymic peptide Beta4 in preparing drugs for preventing and curing bronchial asthma. The test shows that the thymic peptide Beta4 can increase the tidal volume, reduce the breathing frequency and improve the pulmonary ventilation function of a mouse; the thymic peptide Beta4 can inhibit the hyperfunction of a Th2 cell subgroup, reduce the generation of IL-5 and prevent eosinophile granulocyte from aggregating and adhering so as to alleviate the inflammation of an airway and lung tissue; the thymic peptide Beta4 adopts the ways to interfere the occurrence of asthma, alleviate the symptoms of the asthma, defer the irreversibility of airway obstruction and recover the lung function level of the asthma. The application of the invention provides a base for new drug screening.

Description

Application of thymosin β4 in the preparation of drugs for preventing and treating bronchial asthma (1) Technical field The invention relates to the application of thymosin β4 in the preparation of medicines for preventing and treating bronchial asthma. (2) Background technology Bronchial asthma (bronchialasthma, referred to as asthma) is a common and refractory respiratory disease in the world. There are about 160 million asthma patients in the world (Ma Yanliang, He Quanying. From the epidemiological investigation of asthma to see the problem of underdiagnosis of asthma in my country, Chinese Journal of Respiratory and Critical Care, Jan, 2004, Vol.3, No.1), and worldwide Both the morbidity and mortality of asthma are on the rise. Asthma not only directly affects the health of patients, but also becomes a serious social problem and increases the serious economic burden to the society. Therefore, the prevention and treatment of asthma has extremely high social significanc...

AI Technical Summary

Problems solved by technology

Modern medical treatment of asthma uses glucocorticoids as the most effective anti-asthma and anti-inflammatory drugs. As asthma is a chronic persistent inflammation that requires long-term medication, the patient has a series of adverse reactions, mainly manifested as: Fungal infection, hoarseness, long-term large doses can also cause hypertension, diabetes, gastroduodenal ulcer bleeding, osteoporosis and femoral head necrosis, etc., making patients fear hormone therapy

Clinically, cromolyn sodium, anti-leukotriene drugs and other anti-inflammatory, bronchodilator drugs, and immune methods are also used to treat asthma, but the effect is not very good

There is no report on the application of thymosin β4 in bronchial asthma

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