Preparation method of hydroxyapatite nano pole

A technology of hydroxyapatite and nanorods, which is applied in the direction of medical preparations, dental preparations, and pharmaceutical formulations of non-active ingredients, can solve the problems of high cost of linoleic acid and hinder promotion, and achieve controllable shape uniform effect

Inactive Publication Date: 2008-11-05
SOUTHEAST UNIV
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Problems solved by technology

However, the high cost of linoleic a...

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0026] 1 Measure 16ml of oleic acid and 64ml of absolute ethanol, and slowly add 6.4g of sodium oleate while stirring to make it evenly mixed;

[0027] 2 Weigh 2g of calcium nitrate and dissolve it in 30ml of distilled water;

[0028] 3 Slowly pour the calcium nitrate solution into the mixed solution of sodium oleate, ethanol and oleic acid, and mix it evenly with a magnetic stirrer;

[0029] 4 Stir the above solution for 30 minutes to complete the ion exchange;

[0030] 5 Weigh 2g of sodium phosphate and dissolve in 30ml of distilled water;

[0031] 6 Sodium phosphate solution was added into the ion-exchanged solution, and stirred for 5 minutes;

[0032] 7. Pour the above mixed solution into the reaction kettle, and put the reaction kettle in an electric heating constant temperature drying oven, and make it react at 90°C for 8 hours;

[0033] 8. The reaction product was taken out, washed with water, ethanol and ethyl acetate and centrifuged three times in sequence. After d...

Embodiment 2

[0035] The reaction temperature of the reactor in Example 1 was raised to 120 degrees Celsius, and other conditions were the same to obtain hydroxyapatite nanorods with a diameter of about 20 nm and a length of about 100 nm.

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Abstract

The invention discloses a preparation method of a hydroxyapatite nano-rod, which adopts an oleic acid-ethanol-water phase transfer system with low cost to prepare the hydroxyapatite nano-rod with uniform size, controllable appearance and nano-scale. The hydroxyapatite nano-rod is prepared by the steps as follows: a. firstly, the oleic acid, ethanol and an additive are mixed; b. secondly, a calcium salt aqueous solution is dispersed into the oleic acid-ethanol mixed medium; the volume content of the calcium salt aqueous solution in a final mixed solution is 5 percent to 15 percent; the mass volume concentration of the calcium salt is 0.1 percent to 10 percent; c. then,a phosphate aqueous solution is added and mixed at room temperature; the mass volume concentration of the phosphate is 0.1 percent to 10 percent; d. the mixture generated from step c reacts in a reactor between 80 DEG C and 200 DEG C; e. centrifugation is carried out to remove a supernatant fluid and the obtained object is washed by a cleaning solvent and then dried so as to obtain the hydroxyapatite nano-rod. The preparation method is characterized by low production cost and comparatively high product quality, thus being hopeful to be applied in the medical field.

Description

technical field [0001] The invention relates to a method for preparing a hydroxyapatite nanorod, in particular to synthesizing a high-performance hydroxyapatite nanorod with uniform size and controllability by using a cheap oleic acid-ethanol-water phase transfer system. The invention belongs to the technical field of medical hydroxyapatite manufacture. Background technique [0002] Hydroxyapatite (hydroxyapatite, HA), molecular formula Ca 10 (PO 4 ) 6 (OH) 2 , which is a needle-like crystal. The main inorganic component of animal bones and teeth in nature is hydroxyapatite. In bone, hydroxyapatite accounts for about 60%. Hydroxyapatite has excellent biocompatibility, and is currently widely used in fields including bone tissue engineering scaffolds, surface modification of implanted devices, artificial teeth, and drug sustained release, and has achieved good social and economic benefits. [0003] The sources of hydroxyapatite include natural bone extraction and artif...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L31/02A61K47/04A61K6/033A61K6/838
Inventor 张继中
Owner SOUTHEAST UNIV
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