Anti-coccidium microemulsion containing toltrazuril and preparation method thereof

Abstract

The invention provides an anti-coccidial microemulsion, which contains toltrazuril, an oil phase, a surfactant, a cosurfactant and water. The invention also provides a method for preparing the anti-coccidial microemulsion, which comprises the steps of dissolving toltrazuril in a small quantity of oil phase, adding a certain amount of surfactant and cosurfactant, emulsifying with a certain method to make into nanometer oil-in-water type microemulsion. The inventive anti-coccidial microemulsion remarkably reduces the cost of pharmaceutical preparations, reduces the use of organic solvents, and reduces environmental pollution. The microemulsion can be added into the drinking water for livestock and poultry may with uniform dispersion and without drug separation out, resulting in uniform ingestion of the livestock and poultry and no toxic action.

Description

technical field [0001] The invention belongs to the field of veterinary drug microemulsions, in particular to an anticoccidial microemulsion containing toltrazuril and a preparation method thereof. Background technique [0002] Coccidiosis is a disease that causes huge losses in animal husbandry production. It is mainly caused by Eimeria spp., leading to intestinal necrosis, diarrhea, enteritis and death of livestock and poultry. Even minor infections can also cause The decline in feed conversion rate, weight gain reduction and growth retardation cause the loss of economic benefits. For example, the annual loss caused by chicken coccidiosis in my country is as high as 500 million yuan. [0003] Toltrazuril is a triazinone compound, which was successfully developed by Bayer Company of Germany in the 1980s. It can effectively kill many protozoa including Eimeria, and it is especially effective for tender, heap-shaped, giant, and The 6 kinds of Eimeria such as poisonous, brucei...

AI Technical Summary

Problems solved by technology

Because the dosage is small, it is easy to cause uneven mixing of the premix and uneven ingestion of livestock and poultry, resulting in low curative effect or excessive ingestion of individual livestock and poultry, resulting in toxic effects; and solutions are currently organic solvent solutions, a large amount of organic solvents The use of organic solvents is limited in the selection of transportation, storage and containers, resulting in increased costs, and a large amount of organic solvents also pollute the environment, and when added to livestock and poultry drinking water, drug precipitation will occur, which will also affect the curative effect. have a certain impact