Anti-coccidium microemulsion containing toltrazuril and preparation method thereof

A technology of toltrazuril and microemulsion, which is applied in the direction of anti-infective drugs, emulsion delivery, active ingredients of heterocyclic compounds, etc., can solve the problems of environmental pollution, drug precipitation, low curative effect, etc., to reduce environmental pollution and facilitate storage , cost reduction effect

Active Publication Date: 2009-01-07
长沙伟嘉饲料有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the dosage is small, it is easy to cause uneven mixing of the premix and uneven ingestion of livestock and poultry, resulting in low curative effect or excessive ingestion of individual livestock and poultry, resulting in toxic effects; and solutions are currently organic solvent solutions, a large amount of organic solvents The use of organic solvents is limited in the selection of transportation, storage and containers, resulting in increased costs, and a large amount of organic solvents also pollute the environment, and when added to livestock and poultry drinking water, drug precipitation will occur, which will also affect the curative effect. have a certain impact

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: 0.1% Toltrazuril microemulsion

[0032] prescription:

[0033] Raw material prescription quantity

[0034] Toltrazuril 3mg

[0035] Benzaze-30 0.05g

[0036] Polyethylene glycol 200 0.04g

[0037] Span 60 0.06g

[0038] soybean oil 0.3g

[0039] Water up to 3.0g

[0040] Preparation method:

[0041] Weigh the prescribed amount of Toltrazuril, add the prescribed amount of soybean oil, then take the prescribed amount of Benzaze-30, Polyethylene Glycol 200, and Span 60 and mix them evenly, then mix the two solutions evenly, and wait for the toltrazuril to dissolve. Toltrazuril is completely dissolved, and then a sufficient amount of water is added and mixed to obtain 0.1% toltrazuril microemulsion.

[0042] The above solution was measured by a zetasizer 3000HS-nanometer particle size analyzer: the microemulsion particle size distribution was between 25-95nm, of which 26.9% were at 41.6nm, 38.2% were at 50.9nm, and 21.7% were at 62.1nm. Microemulsion ...

Embodiment 2

[0043] Embodiment 2: 0.5% Toltrazuril microemulsion

[0044] prescription:

[0045] Raw material prescription quantity

[0046] Toltrazuril 15mg

[0047] Emulsifier OP 0.1g

[0048] Macrogol 200 0.1g

[0049] Tween 80 0.2g

[0050] Ethyl butyrate 0.3g

[0051] Water up to 3.0g

[0052] Preparation method:

[0053] Weigh the prescribed amount of Toltrazuril, add the prescribed amount of ethyl butyrate, then take the prescribed amount of emulsifier OP, polyethylene glycol 200, and Tween 80 and mix well, then mix the two solutions, and wait until The toltrazuril is completely dissolved, then a sufficient amount of water is added, and the mixture is uniformly mixed to obtain 0.5% toltrazuril microemulsion.

[0054] The above solution is measured by a zetasizer 3000HS-nanometer particle size analyzer: the microemulsion particle size distribution is between 25-95nm, and the microemulsion particle size between 40-65nm accounts for more than 85%.

Embodiment 3

[0055] Embodiment 3: 1% Toltrazuril microemulsion

[0056] prescription:

[0057] Raw material prescription quantity

[0058] Toltrazuril 30mg

[0059] Emulsifier OP 0.4g

[0060] Macrogol 400 0.2g

[0061] Tween 80 0.4g

[0062] Ethyl acetate 0.5g

[0063] Water up to 3.0g

[0064] Preparation method:

[0065] Weigh the prescribed amount of Toltrazuril, add the prescribed amount of ethyl acetate, then take the prescribed amount of emulsifier OP, polyethylene glycol 400, and Tween 80 and mix well, then mix the two solutions, and wait until the toltrazuril Toltrazuril is completely dissolved, then a sufficient amount of water is added, and mixed to obtain 1% Toltrazuril microemulsion.

[0066] The above solution is measured by a zetasizer 3000HS-nanometer particle size analyzer: the microemulsion particle size distribution is between 25-95nm, and the microemulsion particle size between 40-65nm accounts for more than 85%.

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PUM

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Abstract

The invention provides an anti-coccidial microemulsion, which contains toltrazuril, an oil phase, a surfactant, a cosurfactant and water. The invention also provides a method for preparing the anti-coccidial microemulsion, which comprises the steps of dissolving toltrazuril in a small quantity of oil phase, adding a certain amount of surfactant and cosurfactant, emulsifying with a certain method to make into nanometer oil-in-water type microemulsion. The inventive anti-coccidial microemulsion remarkably reduces the cost of pharmaceutical preparations, reduces the use of organic solvents, and reduces environmental pollution. The microemulsion can be added into the drinking water for livestock and poultry may with uniform dispersion and without drug separation out, resulting in uniform ingestion of the livestock and poultry and no toxic action.

Description

technical field [0001] The invention belongs to the field of veterinary drug microemulsions, in particular to an anticoccidial microemulsion containing toltrazuril and a preparation method thereof. Background technique [0002] Coccidiosis is a disease that causes huge losses in animal husbandry production. It is mainly caused by Eimeria spp., leading to intestinal necrosis, diarrhea, enteritis and death of livestock and poultry. Even minor infections can also cause The decline in feed conversion rate, weight gain reduction and growth retardation cause the loss of economic benefits. For example, the annual loss caused by chicken coccidiosis in my country is as high as 500 million yuan. [0003] Toltrazuril is a triazinone compound, which was successfully developed by Bayer Company of Germany in the 1980s. It can effectively kill many protozoa including Eimeria, and it is especially effective for tender, heap-shaped, giant, and The 6 kinds of Eimeria such as poisonous, brucei...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/53A61P33/02
Inventor 梁伟肖凤英伍冶金忠辉
Owner 长沙伟嘉饲料有限公司
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