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Use of annonaceous acetogenins in preparing medicine for treating lung cancer or breast cancer

A technology of anemone lactones and compounds, which is applied in the field of preparation of drugs for treating lung cancer or breast cancer, can solve the problems of unsatisfactory curative effect, low cancer curative effect, and large toxic and side effects, and achieve the effect of improving the clinical curative effect of anti-cancer

Inactive Publication Date: 2009-01-07
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemotherapeutic drugs have a certain effect on cancer, but they have severe side effects

Method used

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  • Use of annonaceous acetogenins in preparing medicine for treating lung cancer or breast cancer
  • Use of annonaceous acetogenins in preparing medicine for treating lung cancer or breast cancer
  • Use of annonaceous acetogenins in preparing medicine for treating lung cancer or breast cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Inhibitory effect of annonareticin, an annonareticin monomer, on transplanted lung cancer

[0017] 1. Experimental animals and tumor strains

[0018] Male healthy C57BL / 6 mice, weighing 18-22 g, aged 6-8 weeks, were purchased from the Animal Experiment Center of our school; mouse Lewis lung cancer tumor strains were purchased from the Animal Experiment Center of Jiangsu Cancer Institute.

[0019] 2. Modeling and experimental methods

[0020] There were 60 C57BL / 6 mice, 10 were randomly reserved in proportion as the negative control group, and the remaining 50 were used for modeling. Prepare Lewis lung cancer tumor-bearing mice, peel off the tumor tissue in the vigorous growth period, and select a well-growing tumor of 1.5mm 3 Left and right, homogenate according to the ratio of tumor (g): normal saline (ml) 1:3, adjust the number of cells to 2×10 6 / ml. Select healthy mice, and inoculate 0.2 ml subcutaneously in the right axilla of each mouse under asepti...

Embodiment 2

[0027] Example 2: Inhibitory effect of annonareticin, an annonareticin monomer, on transplanted breast cancer

[0028] 2. Experimental animals and tumor strains

[0029] Female healthy TA2 mice, weighing 18-22 g, aged 6-8 weeks, were purchased from the Animal Experiment Center of our school; the mouse breast cancer cell line MA-891 was purchased from the Animal Experiment Center of Jiangsu Cancer Institute.

[0030] 2. Modeling and experimental methods

[0031] There were 60 TA2 mice, 10 were randomly reserved in proportion as the negative control group, and the remaining 50 were used for modeling. Take MA-891 mouse breast cancer cells in logarithmic growth phase cultured in vitro, and adjust the cell concentration to 1×10 7 / ml. Under sterile conditions, MA-891 mouse breast cancer cells were inoculated subcutaneously in the right axilla of TA2 mice, the inoculation volume was 0.2ml / mouse (the number of cells was 2×10 6 / Only). The entire inoculation process must be carri...

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PUM

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Abstract

The invention discloses a new application of an annonaceous acetogenin monomeric compound annonareticin in preparing medicaments for treating lung cancer and breast cancer. The results of antitumor pharmacological tests in animals indicate that the annonaceous acetogenin monomeric compound annonareticin has distinct inhibitor action on the growth of lung cancer and breast cancer cells, and has antitumor activity hundreds of times higher than the chemotherapeutic drug 5-flurouracil. The annonareticin can be used for preparing medicaments for treating lung cancer and breast cancer.

Description

1. Technical field [0001] The invention relates to a new application of annonareticin, an annonareticin compound monomer, and the application of the compound in the preparation of medicines for treating lung cancer or breast cancer. 2. Background technology [0002] Cancer is a formidable enemy that endangers human health. There are about 1.6 million new cancer cases in my country every year, and about 1.3 million people die from cancer every year. The number of deaths due to cancer in the country is increasing year by year. my country is a high-incidence area for lung cancer, breast cancer, liver cancer and other cancers. Cancer mortality stay high. [0003] There are currently no effective drugs that cure most cancer patients. Although chemotherapeutic drugs have certain curative effects on cancer, they have severe side effects, and Chinese patent medicines generally have low curative effects on cancer, and the curative effects are not ideal. [0004] The present invento...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K36/185A61P35/00
Inventor 章永红
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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