Compound medicine effective ingredient pharmacokinetics and efficacy analysis method

A technology of active ingredients and analysis methods, applied in special data processing applications, instruments, electrical digital data processing, etc., can solve the cumbersome and difficult calculation operations of pharmacokinetics and pharmacodynamics parameters, mathematical methods and computer software are constantly updated, etc. question

Inactive Publication Date: 2009-01-07
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mathematical methods and computer software that assist the pharmacokinetics-pharmacodynamics research of traditional Chinese medicine have not been continuously updated with t...

Method used

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  • Compound medicine effective ingredient pharmacokinetics and efficacy analysis method
  • Compound medicine effective ingredient pharmacokinetics and efficacy analysis method
  • Compound medicine effective ingredient pharmacokinetics and efficacy analysis method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030]The present invention is applied to the research on the pharmacokinetics and pharmacodynamics of the multi-component in vivo of a certain Chinese patent medicine.

[0031] 1) Obtain the drug time experimental data through experiments:

[0032] As shown in Table 1 below, when rats take multi-component Chinese patent medicines orally, the concentration of components 1 to 5 (concentration unit is ng / ml) changes according to the experimental data of drug time according to time.

[0033] Table 1 Data when rats take a certain Chinese patent medicine orally (concentration unit: ng / mL)

[0034]

[0035] 2) Obtain the time-effect experimental data of the time and effect of individual administration of each component through experiments:

[0036] Table 2 shows the effect on effect indicators I and II when rats take multi-component Chinese patent medicines orally, and the impact of single-component drugs on effect indicators I and II is shown in Table 3 and Table 4.

[0037] T...

Embodiment 2

[0077] The invention is applied to the study of the kinetics of single-component drugs in vivo.

[0078] The pharmacokinetic model is a two-chamber intravenous injection, and the fitting method is a pattern search method.

[0079] The experimental data and analysis results are shown in Table 12 and Table 13 below:

[0080] Table 12 Pharmacokinetic analysis results

[0081]

[0082] Note: *C: Concentration estimated value Pharmacokinetic parameter column element sequence (A, α, B, β) T

[0083] Table 13 Comparison of pharmacokinetic parameters and literature values

[0084]

[0085] The fitting result is as Figure 10 shown.

[0086] The results show that the parameters calculated by this software are the same as the data that can be calculated by the current calculation software (reported in literature), and this software also increases the calculation of other parameters together.

Embodiment 3

[0088] The invention is applied to the research on the pharmacokinetic and pharmacodynamic combination model of the single-component medicine in vivo. The pharmacokinetic model is two-chamber intravenous injection, and the fitting method is the accelerated simplex method. The experimental data and analysis results are shown in Table 14 and Table 15.

[0089] Table 14 pharmacokinetic analysis results

[0090]

[0091] Note: *C: Estimated value of concentration; sequence of elements in pharmacokinetic parameter column (A, α, B, β) T

[0092] Table 15 Pharmacokinetic and pharmacodynamic combination analysis results

[0093]

[0094] Note: *E: experimental value of effect (urine output), E: estimated value of effect

[0095] In this embodiment, the time corresponding to the blood drug concentration fitting curve is as follows: Figure 11 Shown; Pharmacokinetic and pharmacodynamic analysis results are as follows Figure 12 shown.

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Abstract

The invention discloses a pharmacokinetic-pharmacodynamic analytical method for effective components of compound drugs, the pharmacokinetic-pharmacodynamic combination model program of which comprises a pharmacodynamic parameter computation model and a pharmacokinetic parameter computation model. The analytical method comprises the following steps: the test data of a plurality of groups of drugs are read; a pharmacokinetic model is selected for model fitting and the computation of pharmacokinetic parameters; divided weight coefficients of each group are input for the computation of synthesized pharmacokinetic coefficients; a plurality of pharmacodynamic test data are read; drug concentration is computed according to the synthesized pharmacokinetic parameters obtained; the pharmacokinetic model is selected for the fitting of pharmacokinetic-pharmacodynamic parameters; the maximum pharmacodynamic parameter is computed and effect estimation values are output. The pharmacokinetic-pharmacodynamic analytical method for effective components of compound drugs can take the contribution relationship of varying effective components in the compound drugs to synthesized drug effects into consideration according to the effect-time curve area, meanwhile, a plurality of groups of data can be read for analysis and the synthesized pharmacokinetic-pharmacodynamic parameters of the compound drugs are computed to provide better guide to clinical medication.

Description

technical field [0001] The invention relates to the field of pharmacokinetics and pharmacodynamics in mathematical pharmacology, in particular to a method for analyzing pharmacokinetics and pharmacodynamics of active ingredients of compound medicines. Background technique [0002] The pharmacokinetics of traditional Chinese medicine has achieved many new achievements through the rapid development of more than 20 years. Under the guidance of the theory of traditional Chinese medicine, using the principle of kinetics and mathematical processing methods, it is possible to quantitatively describe the dynamic changes of the absorption, distribution, metabolism and other processes of the active ingredients of traditional Chinese medicine, single Chinese medicine and traditional Chinese medicine compound after entering the body through various channels law. [0003] After the drug enters the human body, it is observed that the blood drug concentration changes with time, and the ef...

Claims

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Application Information

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IPC IPC(8): G06F19/00
Inventor 安叡王新宏陈少清黄坚姚亚敏
Owner SHANGHAI UNIV OF T C M
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