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A kind of preparation method of biocompatible aqueous phase quantum dot
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A biocompatible and quantum dot technology, applied in the field of preparation of water-phase quantum dots, can solve the problems of incompatibility between oil-phase quantum dots and biological systems, poor stability of quantum dots, etc., and achieve easy control, simple method, and uniform grain size The effect of diameter distribution
Inactive Publication Date: 2012-02-01
SHANGHAI INST OF TECHNICAL PHYSICS - CHINESE ACAD OF SCI
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[0003] The purpose of the present invention is to provide a simple and feasible method for preparing biocompatible water-based quantum dots by surface modification of quantum dots, which solves the problem of incompatibility between oil phase quantum dots and biological systems, and overcomes the problem of quantum dots prepared in water phase. The difficulty of poor dot stability makes the application of quantum dots in biology simpler and more convenient
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Embodiment 1
[0031] Preparation of nuclear quantum dots: Take the preparation of CdSe cores as an example. Take 0.3mmol of CdO and place it in a three-necked flask. Add 0.5ml of oleic acid and 4ml of octadecene to the three-necked flask. Seal the three-necked flask and ventilate with argon. After one hour, heat to 250℃ for ten minutes. At room temperature, 2.5 g of octadecylamine and 0.5 g of TOPO were added to the three-necked flask, and argon was vented for one hour.
[0032] Take 1.8mmol of Se powder and place it in a pear-shaped bottle. The following steps are operated in a vacuum glove box. Take 1.0ml of TOP and 1.5ml of dioctylamine in a pear-shaped bottle, seal and take out. After the Se powder is completely dissolved under ultrasound, TOPSe is obtained.
[0033] Heat the three-necked flask to 282°C, quickly inject TOPSe, take a sample in 60 seconds, pour it into a pear-shaped flask filled with acetone, and centrifuge, and the precipitate is CdSe quantum dots.
[0034] Preparation of co...
Embodiment 2
[0040] Preparation of nuclear quantum dots: Take the preparation of CdSe quantum dots as an example. Take 0.3mmol of CdO and place it in a three-necked flask. Add 0.8ml of oleic acid and 6ml of octadecene to the three-necked flask. Seal the three-necked flask and ventilate with argon. After one hour, heat to 250°C for ten minutes. At room temperature, 3g of octadecylamine and 0.8g TOPO were added to the three-necked flask, and argon was vented for one hour.
[0041] Take 1.0 mmol of Se powder and place it in a pear-shaped bottle. The following steps are operated in a vacuum glove box. Take 0.6ml of TOP and 1.0ml of dioctylamine in a pear-shaped bottle, seal and take out. After the Se powder is completely dissolved under ultrasound, TOPSe is obtained.
[0042] Heat the three-necked flask to 282°C, quickly inject TOPSe, take samples in 20 seconds, and precipitate in acetone. The precipitate is CdSe quantum dots.
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Abstract
The invention discloses a method for preparing biocompatible water-phase quantum dots. The method is to prepare high-quality quantum dots and their core-shell structures, combined with surface modification technology, and utilize the core-shell structure to improve the stability of quantum dots. , and then through the interaction of intermolecular forces, the organic molecular chains on the surface of the quantum dots are changed, and the long-chain organic molecules on the surface of the oil phase quantum dots are changed to biocompatible and water-soluble containing sulfhydryl groups and carboxyl groups or amine groups. The derivatives of small molecules or biomacromolecules can finally obtain biocompatible aqueous quantum dots that can be directly dissolved in phosphate buffer. The invention has the advantages of simple preparation and surface modification methods of quantum dots, easy control of the quality, size and surface properties of quantum dots, and the obtained aqueous phase quantum dots have high fluorescence efficiency, uniform particle size distribution and strong stability, etc. Advantages: The aqueous phase quantum dots prepared by the invention can be used for biological detection, medical diagnosis, energy transfer and the like.
Description
Technical field [0001] The invention relates to a preparation technology of metal oxide quantum dots, in particular to a preparation method of biologically compatible water phase quantum dots. Background technique [0002] Quantum dot nanomaterials have properties such as quantum size effect, quantum interference effect, quantum tunneling effect, Coulomb blocking effect, and nonlinear optical effect, and show broad application prospects in solar cells, sensors, and biomedicine. In recent years, semiconductor quantum dots (such as CdSe, PbSe, etc.) have attracted the attention of scientific researchers. For example, studies have shown that quantum dots of different sizes and different materials have shown unique uses in the construction and performance adjustment of optoelectronic devices. However, considering practical applications, the application of quantum dots in the field of biomedicine is one step ahead of its use in the field of optoelectronics. In particular, biomedical a...
Claims
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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/02C09K11/88
Inventor 葛美英乐阳吴杰孙艳陈鑫戴宁
Owner SHANGHAI INST OF TECHNICAL PHYSICS - CHINESE ACAD OF SCI
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