Method of preparing iodine-125 sealing seed source core

Abstract

The invention discloses a method for preparing an iodine-125 brachytherapy source core for treating tumor, which comprises the following steps: firstly, putting a standby filamentary silver in a 20-80 percent sodium hypochlorite solution, and performing oscillatory reaction at room temperature for one hour so that the surface of the filamentary silver is covered with a layer of compact AgCl deposition; and secondly, putting the filamentary silver into a mixture solution of an acetic acid buffer solution and a Na<125>I solution to react for one hour so that a layer of even and compact Ag<125>I deposition which is firm and hard to fall off is formed on the surface of the filamentary silver. The reagents used in the method are all conventional ones which are convenient to purchase and have low prices; irritant chlorine is not generated in the process of preparation; the surface of the iodine-125 brachytherapy source core is even and compact; the utilization rate of the radioiodine is high; and the process time is short, thus mass production is easy to realize.

Description

Technical field:

[0001] The invention belongs to the technical field of radioactive implantation therapy, and is mainly used for the preparation method of the iodine-125 sealed seed source source core used for implanting brachytherapy in various tumors such as prostate cancer and brain tumors. Background technique:

[0002] Interstitial implantation therapy is to implant radioactive seeds into tumor tissue, and use the rays emitted by the seed source to kill tumor cells and achieve the purpose of treating tumors. Years of clinical application have proved that the iodine-125 sealed seed source implanted in close range The treatment not only has a good curative effect on prostate cancer, but also has a good curative effect on different types of tumors in other parts. It has been reported abroad that seed source implantation therapy is significantly superior to other treatments in the treatment of head and neck, abdominal cavity, and pelvic cavity tumors, recurrence after radio...

Examples

Embodiment Construction

[0026] 1. Source core preparation process: put 120 silver wires with a diameter of 0.5mm and a length of 3mm in a 7ml glass bottle, add 2ml of 60% sodium hypochlorite solution, shake and react at room temperature for 1 hour, take it out, wash it with double distilled water, and dry it in the air spare.

[0027] In a 7ml glass bottle with a stopper, add 0.24ml of 1mg / ml sodium iodide solution and 0.75ml of acetic acid buffer solution with a pH of 2-5 in sequence, mix 120 above-mentioned silver chloride wires, and put them in a 100mCi radioactive sodium iodide solution at room temperature. After reacting for 1 hour, the iodine-125 sealed seed source source core can be obtained.

[0028] 2. Iodine-125 in the residual liquid is reused to prepare the source core process: 5 silver wires are chlorinated according to the method in the embodiment. Take the residual liquid after the iodination reaction, measure its activity as 2.08mCi, add it into a 7ml glass bottle with a stopper, the...

Technical field:

[0001] The invention belongs to the technical field of radioactive implantation therapy, and is mainly used for the preparation method of the iodine-125 sealed seed source source core used for implanting brachytherapy in various tumors such as prostate cancer and brain tumors. Background technique:

[0002] Interstitial implantation therapy is to implant radioactive seeds into tumor tissue, and use the rays emitted by the seed source to kill tumor cells and achieve the purpose of treating tumors. Years of clinical application have proved that the iodine-125 sealed seed source implanted in close range The treatment not only has a good curative effect on prostate cancer, but also has a good curative effect on different types of tumors in other parts. It has been reported abroad that seed source implantation therapy is significantly superior to other treatments in the treatment of head and neck, abdominal cavity, and pelvic cavity tumors, recurrence after radio...

Examples

Embodiment Construction

[0026] 1. Source core preparation process: put 120 silver wires with a diameter of 0.5mm and a length of 3mm in a 7ml glass bottle, add 2ml of 60% sodium hypochlorite solution, shake and react at room temperature for 1 hour, take it out, wash it with double distilled water, and dry it in the air spare.

[0027] In a 7ml glass bottle with a stopper, add 0.24ml of 1mg / ml sodium iodide solution and 0.75ml of acetic acid buffer solution with a pH of 2-5 in sequence, mix 120 above-mentioned silver chloride wires, and put them in a 100mCi radioactive sodium iodide solution at room temperature. After reacting for 1 hour, the iodine-125 sealed seed source source core can be obtained.

[0028] 2. Iodine-125 in the residual liquid is reused to prepare the source core process: 5 silver wires are chlorinated according to the method in the embodiment. Take the residual liquid after the iodination reaction, measure its activity as 2.08mCi, add it into a 7ml glass bottle with a stopper, the...

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