This invention relates to a
continuous flow synthesis method for
hydroquinone, a chemical and pharmaceutical intermediate, belonging to the field of chemical intermediate synthesis. The method for preparing
hydroquinone uses
phenol as a starting material, which undergoes oxidation to obtain p-
benzoquinone, followed by hydrogenation reduction to obtain
hydroquinone. Both steps are performed in a
microreactor system. The synthesis method includes the following steps: (1)
Phenol, catalyst 1, and
organic solvent are prepared as component A, and an oxidant is used as component B. A and B react in a microchannel reactor 1 to obtain intermediate I
benzoquinone; (2) Intermediate I
benzoquinone is mixed with an
organic solvent and reacted with
hydrogen in a microchannel reactor 2 under the action of catalyst 2 to obtain hydroquinone. This invention utilizes a
microreactor system with excellent heat and
mass transfer performance, significantly shortening the reaction time. Both steps are completed within 50 minutes, and the reaction efficiency is high,
energy consumption is low, safety is high,
automation is high, and the environment is
environmentally friendly.