N-substituted arene aniline / polysubstituted diaryl ether compound, preparation and anti-tumor use thereof
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
- Publication Date
- 2009-04-15
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
Technical field:
[0001] The present invention relates to N-substituted aromatic hydrocarbon aniline / multi-substituted diaryl ether compounds or their pharmaceutically acceptable salts with multiple anticancer activities, their preparation method, pharmaceutical composition containing the compound and their use in the preparation of antitumor drugs in the application. Background technique:
[0002] Malignant tumors are common and frequently-occurring diseases that seriously threaten human health. According to the report of the World Health Organization, among the 5 billion people in the world, there are about 9 million new cases every year, and 7 million deaths due to tumors, and there is an increasing trend every year. Among the three major therapies for malignant tumors (surgery, chemotherapy, and radiotherapy), drug therapy plays an important role. In recent years, with the development of molecular biology and people's further understanding of the molecular mechanism of ...