Calibration of a magnetic sensor device

A magnetic sensor and magnetic technology, applied in the direction of measuring devices, magnetic bead-labeled molecules, instruments, etc., can solve the problems of magnetic instability of sensors

Inactive Publication Date: 2009-05-06
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] A problem with magnetic biosensors of the kind described above is that the sensitivity of the magneto-resistive elements and (thus) the effective gain of the entire measuring device is very sensitive to uncontrollable parameters such as magnetic instabilities in the sensor, external magnetic fields , aging, temperature, etc.

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  • Calibration of a magnetic sensor device
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  • Calibration of a magnetic sensor device

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Embodiment Construction

[0036] figure 1 The magnetic sensor device 10 according to the invention is shown in a specific application as a biosensor that detects magnetically interacting particles, such as superparamagnetic beads 2 , in a sample chamber. In terms of sensitivity, specificity, integration, ease of use, and cost, magnetoresistive biochips or biosensors have promising properties in the field of biomolecular diagnostics. Examples of such biochips are described in WO 2003 / 054566, WO 2003 / 054523, WO 2005 / 010542 A2, WO 2005 / 010543 A1 and WO 2005 / 038911 A1, which are hereby incorporated by reference into the present application.

[0037] Biosensors usually consist of figure 1An array (e.g. 100) of sensor devices 10 of the kind shown constitutes, and the biosensor can thus simultaneously measure the concentration of a large number of different target molecules (e.g. proteins, DNA, amino acids, drugs of abuse) in a solution (e.g. blood or saliva) . In one possible example of a binding protocol...

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Abstract

The invention relates to the calibration of the magnetic sensor device comprising magnetic excitation wires (11, 13) and a magnetic sensor element, for example a GMR sensor (12), for measuring reaction fields (B2) generated by magnetic particles (2) in reaction to an excitation field (B1) generated by the excitation wires. The magnetic sensor element (12) can be calibrated by saturating the magnetic particles (2) with a magnetic calibration field (B3). Thus the direct (crosstalk) action of the excitation field (B1) on the magnetic sensor element (12) can be determined without disturbing contributions of the magnetic particles (2).

Description

technical field [0001] The invention relates to a magnetic sensor device comprising at least one magnetic excitation field generator and at least one magnetic sensor element. Furthermore, the invention relates to the use of such a magnetic sensor device and a method for detecting magnetic particles using such a magnetic sensor device. Background technique [0002] From WO 2005 / 010543 A1 and WO 2005 / 010542 A2 a magnetic sensor device is known, which can be used, for example, in microfluidic biosensors for the detection of molecules (e.g. biomolecules) labeled with magnetic beads . The miniature sensor device has an array of sensor cells including wires for generating a magnetic field and a giant magnetoresistance device (GMR) for detecting stray fields generated by magnetic beads. The resistance of the GMR then indicates the number of magnetic beads in the vicinity of the sensor unit. [0003] A problem with magnetic biosensors of the kind described above is that the sensi...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01V13/00G01R33/12
CPCG01R33/12G01V13/00G01R33/093G01R33/1269B82Y25/00G01R33/09
Inventor J·A·H·M·卡尔曼M·W·J·普林斯
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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