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Polyglutamic acid ester microsphere with active surface and preparation method

A technology of polyglutamate and polybenzyl glutamate, applied in the field of polyglutamate microspheres and its preparation

Active Publication Date: 2010-12-22
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since most of the reactions greatly change the hydrophilic and hydrophobic properties of polyglutamic acid, so far there are no reports and applications on the use of such modified polyglutamic acid to synthesize microspheres.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: the synthesis of polybenzyl glutamate (PBLG)

[0024] Put 6.0g of γ-benzylglutamic acid NCA into the flame-baked reaction bottle, ventilate it with nitrogen three times, add 240ml of dry chloroform with a syringe after sealing, after dissolving, add 2.6ml of N-hexylamine, N-dimethylformamide (DMF) solution (0.2mmol / ml) was stirred at room temperature for 120h. The reactant was settled with excess ether, redissolved in a small amount of chloroform, and settled with excess ether to obtain a white solid. Pure PBLG was obtained by vacuum drying at room temperature for 24 hours. The molecular weight is 5000.

Embodiment 2

[0025] Embodiment 2: the synthesis of polybenzyl glutamate (PBLG)

[0026] Put 6.0g of γ-benzylglutamic acid NCA into the reaction bottle baked by flame, ventilate with nitrogen three times, seal it, add 60ml of dry DMF with a syringe, after dissolving, add 1.3ml of n-hexylamine in DMF solution (0.2mmol / ml), and stirred at 40°C for 24h. The reactant was settled with distilled water, redissolved in a small amount of chloroform, and settled with excess ether to obtain a white solid. Pure PBLG was obtained by vacuum drying at room temperature for 24 hours. The molecular weight is 10000.

Embodiment 3

[0027] Embodiment 3: the synthesis of polybenzyl glutamate (PBLG)

[0028] Put 6.0g of γ-benzylglutamic acid NCA into the reaction bottle baked by flame, ventilate with nitrogen three times, seal it, add 80ml of dry dioxane with a syringe, after dissolving, add 0.65ml of n-hexylamine DMF solution (0.2mmol / ml), and stirred at 30°C for 72h. The reactant was settled with ether, redissolved in a small amount of chloroform, and settled with excess ether to obtain a white solid. Pure PBLG was obtained by vacuum drying at room temperature for 24 hours. The molecular weight is 20000.

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Abstract

The invention pertains to a polyglutamate microballoon sphere with an active surface and a preparation method thereof. A compound with functional groups such as chlorine, nitrine, triple bond, double bond and the like at one end and hydroxide radical at the other end, poly benzyl glutamate and the like are adopted to conduct ester exchange reaction to obtain a copolymer of glutamate with a part of lateral chain activated and then the polyglutamate microballoon sphere with the surface containing functional groups is obtained by an emulsification method. The particle size of the polyglutamate microballoon sphere prepared by the method is 0.5 Mu m to 10 Mu m and the functional group content thereof is 0 percent to 100 percent (with respect to the number of the polyglutamate repetitive units); wherein, the number-average molecular weight of the polyglutamate is 5 thousand to 20 thousand and the hydrolysis degree is less than 1 percent (with respect to the number of the polyglutamate). Theprepared polyglutamate microballoon sphere can be applied to biomedical material fields like medicament carriers, sorbing material, separation and purification of base materials, long-range markers, diagnostic medium and the like.

Description

technical field [0001] The invention relates to a polyglutamate microsphere with an active surface and a preparation method thereof. technical background [0002] In recent years, due to the demand in the field of biomedical materials, the research and application of functionalized polymer materials has become one of the hot spots in the combination of new polymers and biomedical fields. Functionalized polymer microspheres have important and extensive application prospects in the field of biomedical materials such as drug carriers, adsorption materials, separation and purification matrices, long-range markers, and diagnostic media. [0003] The usual polymer microspheres are only used as encapsulation materials or fillers for active substances, and the basic polymer components of the microspheres do not have special functional activities. The application of separation and purification, in vivo dynamic monitoring of active substances, etc. is greatly restricted. In fact, th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G69/48C08G69/16C08J3/12C08L77/04
Inventor 黄宇彬郭金山景遐斌陈学思
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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