A kind of magnesium or magnesium alloy surface treatment method that can control the degradation rate

A technology for surface treatment and control of degradation, applied in the field of surface treatment of magnesium or magnesium alloys, can solve the problems of fast hydrogen evolution, affecting clinical treatment effects and human health, and excessive degradation, so as to achieve controllability and biodegradation The effect of speed, surface treatment method is simple and easy

Active Publication Date: 2017-11-21
BEIJING NATON TECH GRP CO LTD
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  • Description
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Problems solved by technology

[0006] In order to overcome the shortcomings of the existing magnesium or magnesium alloy materials in the human physiological environment, the degradation is too fast, the hydrogen evolution rate is too fast, and the clinical treatment effect and human health are affected. The purpose of the present invention is to provide a magnesium or magnesium alloy that can control the degradation rate. Surface treatment method

Method used

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  • A kind of magnesium or magnesium alloy surface treatment method that can control the degradation rate
  • A kind of magnesium or magnesium alloy surface treatment method that can control the degradation rate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Coating treatment of medical magnesium-calcium alloy

[0033] 1. Pretreatment: Use sandpaper to grind the medical magnesium-calcium alloy, and then use 1μm and 0.3μm Al 2 O 3 Polished with polishing powder, then ultrasonically cleaned the polished magnesium-calcium alloy in absolute ethanol for 5-10 min, and cleaned with N 2 Blow-dry; soak the dried magnesium-calcium alloy in a NaOH solution with a mass fraction of 20% for 24h, then wash it with deionized water, N 2 Blow dry.

[0034] 2. Preparation of mussel protein solution: before use, the mussel protein was diluted to 1 mg / mL with 1% citric acid buffer solution, and its pH was adjusted to 4.6 with NaOH solution, for use.

[0035] 3. Soak the magnesium-calcium alloy pretreated in step 1 in the mussel protein solution of step 2 for 1 hour, so that the mussel protein can be fully adsorbed on the surface of the magnesium-calcium alloy to form a protein film layer with a thickness of about 3-5 μm .

[0036...

Embodiment 2

[0037] Example 2 Coating treatment of medical magnesium-calcium alloy

[0038]1. Pretreatment: Use sandpaper to grind the medical magnesium-calcium alloy, and then use 1μm and 0.3μm Al 2 O 3 Polished with polishing powder, and then ultrasonically cleaned the polished magnesium-calcium alloy in absolute ethanol for 5-10 min, and cleaned with N 2 Blow-dry; soak the dried magnesium-calcium alloy in a NaOH solution with a mass fraction of 20% for 24h, then wash it with deionized water, N 2 Blow dry.

[0039] 2. Preparation of mussel protein solution and nano-cerium oxide solution: before use, dilute the mussel protein to 1 mg / mL with 1% citrate buffer solution, adjust its pH to 4.6 with NaOH solution, and use it for later use; Deionized water was prepared with a nano-cerium oxide solution with a concentration of 500 ppm.

[0040] 3. Soak the magnesium-calcium alloy pretreated in step 1 in the mussel protein solution of step 2 for 1 hour, and then soak it in the nano-cerium oxi...

Embodiment 3

[0043] In step 3, the magnesium-calcium alloy was soaked in the mussel protein solution for 1 hour and coated with a layer of protein film, then air-dried for 2 hours, and then the second layer of protein film was coated according to the same operation, and other steps were the same as in Example 1, A double protein film layer is formed on the surface of the magnesium-calcium alloy.

[0044] After the above coating treatment, the corrosion degradation rate of the magnesium-calcium alloy measured by electrochemical impedance spectroscopy was reduced by about 1 / 4 of that before the coating.

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Abstract

The invention provides a method for surface treatment of magnesium or magnesium alloys that can control the degradation rate, using mussel adhesive protein to form a protein film layer on the surface of the magnesium or magnesium alloy, or using mussel adhesive protein and nano cerium oxide particles on the surface A composite film layer is formed on the surface of the magnesium or magnesium alloy. The magnesium or magnesium alloy material treated by the surface treatment method of the present invention can obviously change its degradation rate under physiological environment; the mussel protein and nano cerium oxide materials adopted in the treatment method of the present invention have excellent biocompatibility, and are suitable for The human body is non-toxic and can be applied clinically; the treatment method of the invention is simple and easy to operate, has strong operability, rich raw material resources and low price, and can realize sustainable industrial application.

Description

technical field [0001] The invention relates to the field of metal materials, in particular to a surface treatment method for magnesium or magnesium alloys that can control the degradation rate. Background technique [0002] Self-absorbable human implant materials are an important category of biomaterials. This kind of material can be gradually ablated and absorbed in the human body, and it does not need to be operated again to remove the fixing piece, which can reduce the pain caused by the operation or the discomfort caused by the implant material left in the body. [0003] Magnesium and magnesium alloys are potential human absorbable implant materials. Compared with other biological materials, magnesium and magnesium alloys are rich in resources, the comprehensive mechanical properties of magnesium such as density and elastic modulus are similar to those of human bones, excellent biocompatibility and Biodegradability and other advantages, can be used as bone nails or ste...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C22/02C23C22/07C23C22/73
Inventor 林昌健侯瑞青杨云张艳梅林理文
Owner BEIJING NATON TECH GRP CO LTD
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