Chinese medicine granular formulation to therapy children anorexia and preparation method thereof and detection method

A technology for infantile anorexia and traditional Chinese medicine granules, which can be applied to medical formulas, medical preparations containing active ingredients, measuring devices, etc., and can solve problems such as unstable product content repeatability, poor granule formability, and errors

Active Publication Date: 2009-06-03
GUIZHOU RUNSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the original trial standard of Erpixing Granules, only sucrose was used as an auxiliary material for granulation, and the formability of the granules was poor and easy to absorb moisture; The content and transfer rate of glycosides are low; in large-scale production, due to equipment reasons, the extract cannot be concentrated in a vacuum concentrator to a thick paste with a relative density of 1.35-1.40 (60°C), and must be released from the pipeline before Jacketed pot is used for concentration, so the production process increases, and the probability of extract contamination is also increased; at the same time, because the relative density of the thick paste is too thick, a large amount of water will be added during granulation, resulting i

Method used

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  • Chinese medicine granular formulation to therapy children anorexia and preparation method thereof and detection method
  • Chinese medicine granular formulation to therapy children anorexia and preparation method thereof and detection method
  • Chinese medicine granular formulation to therapy children anorexia and preparation method thereof and detection method

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Effect test

Embodiment 1

[0120]Example 1 of the present invention: Preparation of traditional Chinese medicine granules for treating infantile anorexia: Weigh 320g of hawthorn, 320g of malt, 240g of gallinaceae, 240g of Chinese yam, 160g of coix seed, 240g of white lentils, 96g of tangerine peel, 96g of poria cocos, and 600g of sucrose and dextrin in an appropriate amount; hawthorn, tangerine peel are crushed into coarse powder, according to the percolation method (Chinese Pharmacopoeia 2005 edition one appendix 10) under the liquid extract and extract item, make solvent with 65% ethanol, after soaking for 48 hours, carry out Percolation, the percolation flow rate is 1.1ml / min, collect 2500ml of the filtrate, recover ethanol from the filtrate, concentrate to a thick paste with a relative density of 1.25-1.30 (50°C), and set aside; malt, gallinaceous gold, yam, coix seed , white lentils, and Poria cocos are decocted with water three times, each time for 1 hour, the decoctions are combined, filtered, the...

Embodiment 2

[0121] Embodiment 2 of the present invention: the detection method of the Chinese medicine granule for the treatment of infantile anorexia comprises:

[0122] Properties: The product is brownish-yellow granules; the gas is slightly fragrant, the taste is sweet and sour, slightly bitter.

[0123] Identification: (1) Take 5g of this preparation, grind it finely, add 25ml of ether, heat and reflux for 1 hour, filter, evaporate the filtrate to dryness, add 1ml of methanol to the residue to dissolve, and use it as the test solution; take another ursolic acid reference substance, Add methanol to make a solution containing 1mg per 1ml, as a reference solution; according to the Chinese Pharmacopoeia 2005 edition, an appendix VI B thin-layer chromatography test, draw 10 μl of each of the above two solutions, and place them on the same carboxymethyl cellulose On the silica gel G thin-layer board with sodium as the adhesive, use toluene: ethyl acetate: formic acid = 20:4:0.5 as the devel...

Embodiment 3

[0132] Embodiment 3 of the present invention: the detection method of Chinese medicine granule of the present invention can be:

[0133] Properties: The product is brownish-yellow granules; the gas is slightly fragrant, the taste is sweet and sour, slightly bitter.

[0134] Identification: Take 5g of this preparation, grind it finely, add 25ml of ether, heat and reflux for 1 hour, filter, evaporate the filtrate to dryness, add 1ml of methanol to the residue to dissolve, and use it as the test solution; take another ursolic acid reference substance, add methanol to prepare Make a solution containing 1mg per 1ml, as the reference substance solution; according to the Chinese Pharmacopoeia 2005 edition, an appendix VI B thin-layer chromatography test, draw 10 μl of each of the above two solutions, and place them on the same spot with carboxymethylcellulose sodium as the binding agent respectively. Toluene: ethyl acetate: formic acid = 20:4:0.5 as the developing agent on the silica...

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Abstract

The present invention discloses a Chinese medicine granular formulation to therapy children anorexia and preparation method thereof and detection method. Calculated in weight, it is made by haw thorn 320 units, germinated barley 320 units, the membrane of a chicken's gizzard 240 units, Chinese potato 240 units, coix seed 160 units, white bonavist 240 units, citrus reticulata blanco 96 units, poria cocos wolf 96 units, fine bagasse 600 units and dextrin in certain amount. Compared with the present technology, different adjuvant are selected and the produced granule has good briquettability, greatly improved anti-humidity capability; the improved preparation process make content of hesperidin in completed product and hesperidin conversion rate improved, and concentration process can be directly completed inside decompression concentrator, also no need to add a great amount of water in pellet fabrication process which avoids waste of energy sources, equipment and human energy meanwhile guaranty product quality; new formulated detection method is of high precision, good repetitiveness, good stability, high recovery rate, and reliable result, and can effectively guide production thereby ensure product quality and curative effect.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine granule for treating infantile anorexia, a preparation method and a detection method thereof, and belongs to the technical field of traditional Chinese medicine pharmacy. Background technique: [0002] Erpixing Granules is an over-the-counter pediatric anorexia drug successfully developed by the applicant in the early years and put into production. Stomach, the effect of digestion and accumulation; for children with anorexia caused by spleen deficiency and food stagnation, loose stools, emaciation and infirmity. However, in the original trial standard of Erpixing Granules, only sucrose was used as an auxiliary material for granulation, and the formability of the granules was poor and easy to absorb moisture; The content and transfer rate of glycosides are low; in large-scale production, due to equipment reasons, the extract cannot be concentrated in a vacuum concentrator to a thick paste with a ...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61K9/16A61K47/40A61P1/14G01N30/36G01N30/90
Inventor 郎洪平
Owner GUIZHOU RUNSHENG PHARMA
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