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Gel patch for treating insomnia and method for preparing the same

A gel patch and hydrogel technology, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of high irritation, large side effects, and easy to pollute clothes, etc.

Inactive Publication Date: 2009-07-01
TIANJIN ZHONGBAO PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to combine the advantages of the latest molecular gel and hydrogel, not only overcome the common disadvantages of large side effects of existing oral preparations, but also avoid the poor plasticity of general water-based gels and the irritation of oily gels to the skin. Disadvantages such as large size and easy to contaminate clothes

Method used

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  • Gel patch for treating insomnia and method for preparing the same

Examples

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Effect test

Embodiment

[0028] Penetration enhancer oleic acid, azone 8kg

[0029] Molecular Gel 2.5% Lecithin,

[0030] 97.5% Isopropyl Myristate 100kg

[0031] Hydrogel 8% Sodium Polyacrylate, 2% Polyvinylpyrrolidone

[0032] 2% sodium carboxymethylcellulose, 20% propylene glycol,

[0033] 20% glycerin, 48% deionized water 300kg

[0034] Lily Extract 20kg

[0035] Poria cocos extract 15kg

[0036] Jujube Seed Extract 10kg

[0037] Polygala Extract 10kg

[0038] Preparation:

[0039]Weigh 24kg of sodium polyacrylate, 6kg of polyvinylpyrrolidone and 6kg of sodium carboxymethylcellulose solid powder and mix them uniformly, disperse them in 60kg of propylene glycol and 60kg of glycerin solvent, mix them in a stirrer, add 20kg of lily extract, poria cocos Extract 15kg and 144L of deionized water, mix well, take 97.5kg of isopropyl myristate and put it in a blender, add 10kg of Suanzaoren extract, 10kg of Polygala extract and 8kg of oleic acid and azone,...

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Abstract

The present invention relates to a gel plaster for sleep disorder and its preparation mehtod thereof, composed of 2% -100% of extract of traditional Chinese medicine and 98% -0% of medicinal adjuvant, wherein the extracts of the lily, tuckahoe are the water-soluble extracts using water extraction method and the extracts of spiny jujube seed, polygala root are fat-soluble extracts using alcohol extraction method. The traditional Chinese medicine plaster is prepared by mixing the molecule gel with the hydrogel and the water-soluble medicine enters into the skin through a water-based channel and the fat-soluble medicine enters into the skin by a fat-soluble channel, thus the production technique prevents the separation of medicine and matrix, at the same time a certain repulsion force of oil-based matrix to the water-based medicine and a certain repulsion force of water-based matrix to the oil-based medicine can promote the medicine absorption and the medicine efficacy is increased.

Description

technical field [0001] The invention relates to the newest molecular gel dosage form and hydrogel dosage form in the technical field of transdermal drug delivery preparations, a transdermal absorption gel patch for treating insomnia with traditional Chinese medicine extracts and a medicinal matrix and a preparation method thereof. Background technique [0002] Transdermal drug delivery system or percutaneous absorption patch refers to a type of preparation that is applied through the skin, and the drug is absorbed through the skin into the blood circulation of the whole body and reaches an effective blood concentration to achieve disease treatment or prevention. The characteristic of the transdermal absorption patch is that the transdermal drug delivery system can avoid the first-pass effect of the liver and the inactivation of the drug in the gastrointestinal tract, and the absorption of the drug is not affected by gastrointestinal factors, reducing the individual difference...

Claims

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Application Information

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IPC IPC(8): A61K36/8967A61K9/00A61K9/70A61K47/12A61K47/14A61K47/18A61K47/24A61K47/28A61K47/34A61K47/38A61K47/40A61P25/00
Inventor 高惠明李扬方昊周英超
Owner TIANJIN ZHONGBAO PHARMACY
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