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Application of coumpound baicalin-zinc in preparing medicament for resisting peptic ulcer

A technology of baicalin zinc and baicalin is applied to the application field of compound baicalin zinc in the preparation of anti-peptic ulcer medicines, and can solve the problems of no baicalin zinc and the like.

Inactive Publication Date: 2011-04-06
KUNMING MEDICAL UNIVERSITY
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  • Abstract
  • Description
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Problems solved by technology

[0003] Baicalin zinc is the chemical complex of baicalin and zinc, the main active ingredient of the traditional Chinese medicine Scutellaria baicalensis. Current research believes that baicalin zinc mainly has anti-inflammatory, anti-HIV, anti-allergic and free radical scavenging effects (Li Yanfeng, Liang Shaorong, Geng Hui .Research progress of baicalin metal complexes. Shi Zhen Guo Yi Guo Yao, 1999.10(2): 1152-153. Wang Q, Wang YT, PuSP, Zheng YT.Zinc coupling potentiates anti-HIV-1 activity of baicalin.Biochem.Bioph .Res.Co.2004,324:605-610), but there is no report on the application of baicalin zinc in the treatment of peptic ulcer

Method used

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  • Application of coumpound baicalin-zinc in preparing medicament for resisting peptic ulcer
  • Application of coumpound baicalin-zinc in preparing medicament for resisting peptic ulcer
  • Application of coumpound baicalin-zinc in preparing medicament for resisting peptic ulcer

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Embodiment Construction

[0009] One. The effect of the compound of the present invention on acute gastric ulcer in mice induced by water immersion stress

[0010] 70 healthy female ICR mice were randomly divided into 6 groups with 10 mice in each group, which were model control group, ligand control baicalin group, baicalin zinc high-dose group 0.2mg / kg, baicalin zinc middle-dose group 0.1mg / kg, low dose of baicalin zinc 0.05mg / kg, positive control omeprazole group, zinc gluconate control group. Each group was prepared with 0.5% sodium carboxymethyl cellulose, administered by intragastric administration at 20 ml / kg, once a day, for 6 days in total. One hour after the last administration, the mice were fixed on the mouse clip board, and placed in a constant temperature water bath at 20°C at the level of the xiphoid process for 20 hours of stress to cause stress gastric ulcers. After that, the animals were killed by neck dislocation, and the stomach Put it in 1% formaldehyde and fix it for 10 minutes, ...

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Abstract

The invention relates to new application of compound baicalin-Zn in preparing drugs for resisting peptic ulcers. The baicalin-Zn is prepared into granules, or capsules, or tablets, or pills as drugs or health-care products for treating the peptic ulcers. Preferably, 0.05-0.5 milligram of the drug is orally taken each time and twice or three times each day. The invention shows that the baicalin-Znhas good protection functions to water irritability mouse gastric ulcers and reserpine induced rat gastric ulcers and has equivalent effect to the primary anti-ulcer drug omeprazole usually used in clinics while dosage thereof is only 1 / 80 of the omeprazole. As an orally taken drug and health-care product in the treatment of peptic ulcers, the compound baicalin-Zn has the characteristics of high effect, low toxicity and good development and application prospects as a drug prepared for treating the peptic ulcers.

Description

technical field [0001] The invention belongs to pharmaceutical preparations containing organic active ingredients, and relates to the application of baicalin zinc in treating peptic ulcer. Background technique [0002] Peptic ulcer (peptic ulcer) is a clinically common and frequently-occurring disease, and its formation is related to the digestion of gastric acid and pepsin. Modern research shows [Yang Kedi. Trace Elements and Health [M] Beijing, People's Health Publishing House. 2003: 122-123. Wang Ping, Guo Yulin, Liu Liwei. Determination and Analysis of Serum Zinc and Copper Content in Patients with Peptic Ulcer. Chinese Community Physician Comprehensive Edition. 2004, 6 (18): Feng 3. Hu Fulian, Zhang Xijin, Jia Boqi, etc. Therapeutic effect of zinc acexate in peptic ulcer disease. Chinese Journal of Clinical Pharmacology, 1996, 12 (2): 65.] Zinc is an essential trace element for the human body. It can inhibit the secretion of gastric juice, and can prevent basophils fro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P1/04
Inventor 刘旭李玲杨晖蔡传英田长富陆瑛
Owner KUNMING MEDICAL UNIVERSITY
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