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Stir-fried fructus gardenia dispensing granule as well as preparation method and quality control method thereof

A technology for formula granules and stir-fried gardenia, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, measuring devices, etc., and can solve problems such as difficulty in spectral analysis.

Active Publication Date: 2009-07-08
BEIJING KANGRENTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the fact that Chinese herbal medicines, herbal pieces and Chinese patent medicines are much more complex mixture systems than western medicines, it is difficult to analyze the spectra, so that conventional infrared spectroscopy has not been able to play its due role in the quality control and management of traditional Chinese medicines for a long period of time. the role of

Method used

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  • Stir-fried fructus gardenia dispensing granule as well as preparation method and quality control method thereof
  • Stir-fried fructus gardenia dispensing granule as well as preparation method and quality control method thereof
  • Stir-fried fructus gardenia dispensing granule as well as preparation method and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: Fried gardenia formula granules

[0045] Take 100kg of fried gardenia decoction pieces, add 800kg of water, extract for 2 hours, that is, the first decoction; after the first decoction, add 800kg of water to the dregs, extract for 1.5 hours, that is, the second decoction; combine the two decoctions, concentrate under reduced pressure to a relative density of 1.05 —1.10; the concentrated solution is preheated at 45°C, the inlet air temperature is 180°C, the material pump speed is 550 rpm, the outlet air temperature is 80°C, and the air supply temperature is 45°C, and the spray-dried powder is obtained; Add the auxiliary material dextrin of its own weight portion 0-5% in the fried gardenia spray-dried powder; The fried gardenia spray-dried powder is 5MPa in the pressure of main pinch wheel, and the pressure of side pinch wheel is 0.5MPa, and the spindle speed is 400 rpm According to the dry granulation method, the feeding voltage is 120V to obtain 20-60 mesh...

Embodiment 2

[0046] Embodiment 2: Fried gardenia formula granules

[0047] Take 100kg of fried gardenia decoction pieces, add 1000kg of water, extract for 2 hours, that is, the first decoction; after the first decoction, add 600kg of water to the dregs, extract for 1 hour, that is, the second decoction; combine the two decoctions, concentrate under reduced pressure to a relative density of 1.00 —1.05; the concentrated solution is preheated at 50°C, the inlet air temperature is 170°C, the material pump speed is 600 rpm, the outlet air temperature is 75°C, and the air supply temperature is 50°C, and the spray-dried powder is obtained; Add 5-15% of its own weight of auxiliary material dextrin in the spray-dried gardenia powder; the pressure of the main pressure wheel is 6MPa, the pressure of the side pressure wheel is 0.4MPa, the spindle speed is 450 rpm, and the feeding voltage is 110V Under the condition of dry granulation, 20-60 mesh fried gardenia formula granules are obtained, and every ...

Embodiment 3

[0049] Embodiment 3: Fried gardenia formula granules

[0050] Take 100kg of fried gardenia decoction pieces, add 1400kg of water, extract for 2.5 hours, that is, the first decoction; after the first decoction, add 1100kg of water to the dregs, extract for 2.5 hours, that is, the second decoction; combine the two decoction liquids, and concentrate under reduced pressure to a relative density of 1.10 —1.15; the concentrated solution is preheated at 45°C, the inlet air temperature is 170°C, the material pump speed is 600 rpm, the outlet air temperature is 75°C, and the air supply temperature is 50°C, and the spray-dried powder is obtained; Add 15-25% of its own weight of lactose in the fried gardenia spray-dried powder; the pressure of the main pressure wheel is 4MPa, the pressure of the side pressure wheel is 0.4MPa, the spindle speed is 500 rpm, and the feeding voltage is 130V. Dry granulation to obtain 20-60 mesh fried gardenia formula granules, and each gram of fried gardenia...

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Abstract

The invention discloses a fried gardenia prescription granule, a preparation method and a quality control method thereof. The fried gardenia prescription granule takes fried gardenia decoction pieces as the raw material and the fried gardenia prescription granule is prepared through the process flows, such as twice water extraction, vaccum concentration, sponging drying, and the like; 1g of the fried gardenia prescription granule is equal to 5-10g of crude drug; the content of gardenoside in the fried gardenia prescription granule is not lower than 5%; the quality of both fried gardenia decoction pieces and fried gardenia prescription granule are identified by infrared fingerprint spectra. The fried gardenia prescription granule of the invention has complete and advanced production process, specific and controllable quality control standard scientific, advanced and fast detecting method related to the quality standard and strong operability. A great number of experiments prove that the prepared soup of the fried gardenia prescription granule of the invention and the mixed simmered liquid of the classical prescription decoction pieces containing the fried gardenia have equal components, thus realizing the technique of full ingredient prescription granule and proving the rationality of the technique of the invention; furthermore, the invention applies the infrared spectroscopy technology to the quality control of the traditional Chinese medicines, rapidly solving the primary problem in the macro quality control of the traditional Chinese medicines---the identification of the truth of traditional Chinese medicines.

Description

technical field [0001] The invention relates to a traditional Chinese medicine formula granule, a preparation method and a quality control method thereof, in particular to a fried gardenia formula granule, a preparation method and a quality control method thereof. Background technique [0002] Traditional Chinese medicine formula granules, under the guidance of the theory of traditional Chinese medicine, are made of Chinese herbal decoction pieces through various processes, and are used in clinical prescriptions of traditional Chinese medicine. Compared with traditional Chinese medicine decoction, it is convenient to take and the dosage is small , the quality is controllable, easy to store, and easy to carry; Chinese medicine formula granules are currently in the pilot production state in China, and the product technology and quality standards are not uniform. At present, traditional Chinese medicine formula granules are mostly extracted with water, or extracted with water a...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K9/16A61J3/00G01N21/35G01N21/3563
Inventor 吴玢付静张翠
Owner BEIJING KANGRENTANG PHARMA
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