Anti-hypertension compound, and preparation, pharmaceutical composition and use thereof

Abstract

The invention provides antihypertensive compounds, methods for preparing the same, the pharmaceutical compositions of the same and the uses of the same. The antihypertensive compounds are compounds ofa general formula (I) or pharmaceutically acceptable salts, solvates, polycrystals, antipodes or a racemic mixture of the same, wherein R1, R2, R3, and R4 are H, substituted alkyls, substituted cyclohexyls, substituted alkylthios, substituted alkoxyls, substituted aryls, substituted aralkyls independently, or R1 and R2 form substituted cyclohexyls together, or R2 and R3 form substituted heterocyclyls. The compounds are absorbed by gastrointestinal tracts through the active transportation of a PepT1 transporter, and decomposed by enzymes in intestinal tracts and the liver to form iosartan slowly, so the iosartan is kept in the blood for a longer time and stable blood concentration contributes to the improvement of curative effects and reduction of side reactions.

Description

technical field The invention relates to a class of antihypertensive compounds and a preparation method thereof, as well as pharmaceutical compositions containing the antihypertensive compounds and the use of the antihypertensive compounds in preparing antihypertensive drugs. Background technique Hypertension is a common disease, frequently-occurring disease, and one of the most important risk factors for cardiovascular and cerebrovascular diseases. The main complications of hypertension—stroke, heart disease, and kidney disease—seriously endanger human health, with a high rate of death and disability, and a heavy burden on individuals, families, and society. Due to social and economic development and changes in people's lifestyles, the prevalence of hypertension among Chinese residents has continued to increase. The results of the 2002 National Survey on Nutrition and Health Status of Residents showed that the prevalence of hypertension among adults in my country was as hig...

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Problems solved by technology

In addition, the drug also caused adverse reactions such as hyperglycemia, angioneurotic edema, and acute pancreatitis.

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