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Application of bulleyaconitine A in preparing medicament for treating ache related to sodium channel

A technology of clathrate and channel, which is applied in the application field of clathrate as a medicine for preparing pain related to Na+ channel, and can solve the problems of no anti-inflammatory effect, tolerance and addiction, etc.

Inactive Publication Date: 2009-07-15
YUNNAN HAOPY PHARM LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional opioids are tolerant and addictive for moderate to severe pain, and have no anti-inflammatory effect; non-steroidal anti-inflammatory drugs, such as naproxen, fenbid, etc., are mainly effective for mild to severe pain and inflammation , but no significant effect on moderate to severe pain and inflammation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Each tablet contains 0.1mg of aconitin mixed with excipients to make aconitin tablets.

Embodiment 2

[0026] Each tablet contains 0.3mg of aconitin mixed with excipients and pressed into aconitin tablets.

Embodiment 3

[0028] Each tablet contains 0.5 mg of aconitin mixed with excipients and pressed to make aconitin tablets.

[0029] The excipients added to the above-mentioned Aconitin Tablets are common additional materials that have the functions of filling, binding, disintegrating and lubricating, do not have physical and chemical reactions with drugs, have no physiological effects, are non-toxic, and have no adverse reactions.

[0030] The oral usage and dosage of the above tablets are one tablet at a time, 2 to 3 times a day.

[0031] Considerations include:

[0032] 1. The interval between two medications should not be less than 6 hours to keep the blood drug concentration within the therapeutic window.

[0033] 2. In case of adverse reactions, atropine can be injected intravenously, and the dose can be reduced or discontinued; if the reaction is severe, it should be treated as aconitum poisoning and the drug should be stopped.

[0034] 3. It is forbidden to use this product when its ...

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Abstract

The invention relates to an application of bulleyaconitine A used for preparing medicine for treating pain related to a Nachannel, belonging to medicine containing effective organic ingredients, in particular to medicine using the bulleyaconitine A for treating a disease. The medicine contains excipient which plays roles in padding, bond, disintegration and lubrication; the bulleyaconitine A and the excipient are mixed to be pressed into tablets; and each tablet of bulleyaconitine A contains 0.1mg to 0.5mg of the bulleyaconitine A. The medicine plays obvious roles in resisting pain and inflammation and improving rationalization indexes for wide sodion pain, such as rheumathritis, osteoarthritis, scapulohumeral periarthritis, lumbodorsal fascia inflammation, strain of lumbar muscles, sprain of joints, closed fracture of limbs, sprain, toothache, and the like. The medicine can be rapidly absorbed by oral administration, eliminates the half-life for about 5 hours, and has an excretion pathway by two channels and little toxicity. Compared with opium medicine, the medicine does not generate a tolerant phenomenon in the course of resisting pain, causes no addiction and is convenient for treatment and use as an oral administration preparation.

Description

technical field [0001] The invention belongs to medicines containing effective organic ingredients, in particular to medicines for treating diseases with orthoquinone. Background technique [0002] Na + The pain caused by the channel refers to the activation of the sodium channel on the cell body of the existing DRG neuron and its protruding membrane, which increases the excitability and the discharge frequency, and the feeling is fast pain; followed by changes in molecular structure, such as the type of sodium channel , Quantity changes, distribution and electrophysiological characteristics of the membrane, etc., abnormal discharge occurs, and the feeling is pain sensitivity or slow pain. It includes neuropathic pain and various inflammatory pains caused by peripheral nerve injury. The former causes abnormal discharge due to the reorganization of sodium channels and changes in expression levels after peripheral nerve injury, such as trigeminal neuralgia, sciatica, Posther...

Claims

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Application Information

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IPC IPC(8): A61K31/439A61P29/00A61P25/02
Inventor 李彪
Owner YUNNAN HAOPY PHARM LTD
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