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Ballonflower dispensing granule as well as preparation method and quality control method thereof

A technology of formula granules and platycodon grandiflorum, which is applied in the field of platycodon grandiflorum formula granules and their preparation, and can solve problems such as difficulty in analysing the spectrum

Active Publication Date: 2009-07-15
BEIJING KANGRENTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the fact that Chinese herbal medicines, herbal pieces and Chinese patent medicines are much more complex mixture systems than western medicines, it is difficult to analyze the spectra, so that conventional infrared spectroscopy has not been able to play its due role in the quality control and management of traditional Chinese medicines for a long period of time. the role of

Method used

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  • Ballonflower dispensing granule as well as preparation method and quality control method thereof
  • Ballonflower dispensing granule as well as preparation method and quality control method thereof
  • Ballonflower dispensing granule as well as preparation method and quality control method thereof

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Experimental program
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Effect test

Embodiment 1

[0036] Embodiment 1: Platycodon grandiflorum formula granules

[0037] Take 100kg of Platycodon grandiflora, add 800kg of water, extract for 2 hours, that is, the first decoction; after the first decoction, add 800kg of water to the dregs, extract for 1.5 hours, that is, the second decoction; combine the two decoctions, concentrate under reduced pressure to a relative density of 1.05-1.10 The concentrated solution is preheated at 45°C, the air inlet temperature is 180°C, the material pump speed is 550 rpm, the air outlet temperature is 80°C, and the air delivery temperature is 45°C and spray-dried to obtain a spray-dried platycodon root powder; Add the lactose of its own weight portion 0-5% in the powder; Platycodon grandiflorum spray-dried powder is 5MPa in main pinch roller pressure, and side pinch wheel pressure is 0.5MPa, and spindle speed is 400 rev / mins, and feeding voltage is dried under the condition of 120V. Granules are granulated by method to obtain 20-60 mesh bellf...

Embodiment 2

[0038] Embodiment 2: Platycodon grandiflorum formula granules

[0039] Take 100kg of Platycodon grandiflora decoction pieces, add 1000kg of water, extract for 2 hours, that is, the first decoction; after the first decoction, add 600kg of water to the dregs, extract for 1 hour, that is, the second decoction; combine the two decoction liquids, and concentrate under reduced pressure to a relative density of 1.00-1.05 The concentrated solution is preheated at 50°C, the air inlet temperature is 170°C, the material pump speed is 600 rpm, the outlet temperature is 75°C, and the air delivery temperature is 50°C, and the spray drying is done to obtain the spray-dried powder of bellflower; Add 5-15% of its own weight of auxiliary material dextrin to the powder; dry granulation under the conditions of main pressure roller pressure 6MPa, side pressure roller pressure 0.4MPa, spindle speed 450 rpm, and feeding voltage 110V , to get 20-60 mesh bellflower formula granules, the bellflower for...

Embodiment 3

[0041] Embodiment 3: Platycodon grandiflorum formula granule

[0042] Take 100kg of Platycodon grandiflora decoction pieces, add 1400kg of water, extract for 2.5 hours, that is, the first decoction; after the first decoction, add 1100kg of water to the dregs, extract for 2.5 hours, that is, the second decoction; combine the two decoction liquids, and concentrate under reduced pressure to a relative density of 1.10-1.15 The concentrated solution is preheated at 45°C, the air inlet temperature is 170°C, the material pump speed is 600 rpm, the outlet temperature is 75°C, and the air delivery temperature is 50°C, and the spray drying is done to obtain the spray-dried powder of bellflower; Add the lactose of its own weight portion 15-25% in the powder; Dry granulation under the condition that the main pressure wheel pressure is 4MPa, the side pressure wheel pressure is 0.4MPa, the spindle speed is 500 rev / min, and the feeding voltage is 130V, to obtain 20-60 mesh bellflower formula...

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Abstract

The invention discloses a balloon flower formulation granule, a preparation method and a mass control method thereof. The balloon formulation granule uses balloon flower decoction pieces as raw materials, and is prepared by technological process that the balloon flower decoction pieces are process by twice extraction, vacuum concentration, spray drying, and the like. Each gram of the balloon flower formulation granule is equal to 3-5 grams of crude drugs, and the balloon flower decoction pieces and the balloon flower formulation granule are respectively treated with mass identification by adopting infrared fingerprint spectra. The balloon flower formulation granule is prepared by adopting integrated and advanced production technology and specific and controllable mass control standards; the advanced technology can be realized, and the test methods of the mass standards are scientific, advanced, quick and workable and have strong operability. Large numbers of experiments prove that the components of soup prescribed by the balloon flower formulation granule are equal to the components of soup containing classical balloon pieces square decoction pieces, full-component formulation granule technology is realized, and the reasonableness of the technology of the invention is proved; in addition, the invention applies the infrared spectrum technology in the mass control of traditional Chinese medicine, and quickly solves the identification of the truth of traditional Chinese medicine, which is an important problem in the macroscopical mass control of traditional Chinese medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine formula granule and its preparation method and quality control method, in particular to a platycodon grandiflorum formula granule and its preparation method and quality control method. Background technique [0002] Traditional Chinese medicine formula granules, under the guidance of the theory of traditional Chinese medicine, are made of Chinese herbal decoction pieces through various processes, and are used in clinical prescriptions of traditional Chinese medicine. Compared with traditional Chinese medicine decoction, it is convenient to take and the dosage is small , the quality is controllable, easy to store, and easy to carry; Chinese medicine formula granules are currently in the pilot production state in China, and the product technology and quality standards are not uniform. At present, traditional Chinese medicine formula granules are mostly extracted with water, or extracted with water af...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/34A61K9/16A61J3/00G01N21/35G01N21/3563
Inventor 吴玢付静张翠
Owner BEIJING KANGRENTANG PHARMA