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Adsorption carrier containing composite fiber

An adsorption carrier and composite fiber technology, which is applied in the direction of suction equipment, material separation, material inspection products, etc., can solve the problems of poor shape retention, reduced adsorption function, easy blood clogging, etc., and achieve excellent shape stability and pressure loss. The effect of small, increased import volume

Inactive Publication Date: 2012-08-08
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Here, although it is proposed about the adsorption of toxins and cytokines, it cannot be endowed with the function of cell adsorption
[0005] On the other hand, if the bulk density of the adsorption carrier is too large, the treated blood will easily clog, on the contrary, if it is too small, the shape retention of the adsorption carrier will deteriorate, so the bulk density is 0.05 to 0.15 g / cm 3 is important, although it is disclosed to use preferably 0.10-0.15g / cm 3 carrier (Patent Document 6), but at 0.05-0.10g / cm 3 Poor shape stability in the range of 0.10 ~ 0.15g / cm 3 Within the range and practical adsorption carrier has not been developed
In addition, a cell-adsorbing material including core-sheath or island-in-the-sea composite fibers (having a fiber diameter of 10 μm or less) and conventional fibers (having a fiber diameter of 10 μm or more) is disclosed, although cells are adsorbed by the former, but due to the small fiber diameter, it has an adsorption function Part of it will be blocked by the adsorbed cells, and there is a problem that the adsorption function will decrease in a short time

Method used

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  • Adsorption carrier containing composite fiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] 50 ml of blood (hematocrit value: 43%) was collected from healthy volunteers with heparin blood collection (heparin concentration 10 U / ml), and human natural IL-6 manufactured by Kamakura Technoscience Co., Ltd. was added thereto and dissolved to make the concentration 500 pg / ml. ml.

[0105] Laminate 140 mg of AC-1 along the axial direction and fill it into a cylindrical column with an internal volume of 2 ml and a cross-sectional diameter perpendicular to the axial direction of 1 cm. Circulate 25 ml of the above blood at 37°C for 1 hour at a flow rate of 2.0ml / min, after that, the composition of blood cells was analyzed with an automatic blood analyzer, and the amount of IL-6 was quantified. For subsequent quantification, an IL-6 quantification kit manufactured by Toraykamakura Technoscience was used. As a result, the reduction rates (removal rates) of the number of lymphocytes, granulocytes, monocytes, and IL-6 in the blood after the circulation are shown in Table 1...

Embodiment 2

[0109] Using 190 mg of AC-1 and the same column as in Example 1, a column filled with the carrier was produced in the same manner as in Example 1, and the test was performed under the same conditions as in Example 1. As a result, the removal rate of each substance is shown in Table 1. In addition, the maximum value of the column pressure loss was 68 mmHg at the end of the cycle at the point after 1 hour of circulation.

Embodiment 3

[0137]150 mg of AC-3 was filled in the same cylindrical column as in Example 1 in the same manner as in Example 1, and the test was performed under the same conditions as in Example 1. As a result, the removal rate of each substance is shown in Table 1. At this time, the maximum value of the column pressure loss was 52 mmHg at the end of the cycle at the time after 1 hour of circulation, and there was no problem.

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Abstract

Disclosed is an adsorption carrier which can remove a cell occurring in the blood, preferably an activated leukocyte such as a granulocyte or a monocyte or a cancer cell, more preferably a cytokine present in an excessive amount, and which has a significantly increased cytokine-adsorbing ability compared to a conventional technique. The adsorption carrier comprises a fiber A having a diameter of 0.5 to 8 [mu]m inclusive and a fiber B having a diameter of 8 to 50 [mu]m inclusive, wherein the diameter of the fiber B is larger than that of the fiber A, and the fiber B comprises a sheath-core-type or island-sea-type composite fiber.

Description

technical field [0001] The present invention relates to a novel adsorption carrier, in particular to an adsorption carrier suitable for a blood treatment column used by allowing blood components to pass through. Furthermore, it relates to a blood treatment column incorporating the adsorption carrier of the present invention as an adsorbent module suitable for adsorbing and removing cells and humoral factors (liquid factors) present in blood. Background technique [0002] In recent years, various blood processing columns have been studied, for example, columns for the purpose of removing leukocytes and granulocytes (Patent Documents 1 and 2), and columns for the purpose of adsorbing toxins and cytokines have been developed respectively (Patent Documents 1 and 2). Documents 3 and 4), a column for simultaneously adsorbing leukocytes and toxins (Patent Document 5), and the like. Usually, the interior of these columns has filter materials or adsorption carriers for removing and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/36B01J20/26D04H1/42
CPCB01J20/26B01J20/3293B01J20/3297D04H13/007D04H13/003B01J2220/66B01J20/3251B01J20/321B01J20/3248B01J20/28004A61M1/3679B01J20/28023D04H13/002B01J20/3227B01J20/28033D04H1/46D04H1/43828D04H1/43835D04H1/43838D04H1/4383G01N33/49G01N30/00
Inventor 岛垣昌明
Owner TORAY IND INC
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