Stable thickening type quaternary ammonium salt composition
A composition and quaternary ammonium salt technology are applied in the field of thickened quaternary ammonium salt compositions, which can solve the problems of short residence time, single dosage form, few varieties, etc. Effect
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Embodiment 1
[0014] Embodiment 1, the preparation of the thickening type quaternary ammonium salt composition of stabilization
[0015] Unless otherwise specified, the sample contains 10% benzyltrimethylammonium chloride and 0.6%-1.2% hydroxypropyl cellulose. The preparation method of the composition is: mix hydroxypropyl cellulose with purified water, stir well, After the liquid is stable, slowly add benzyltrimethylammonium chloride solution (converted content) while stirring; add 0.5% water quality lemon essence, then use purified water to make up the volume, and after fully stirring, the thickened quaternary ammonium salt composition is obtained.
Embodiment 2
[0016] Embodiment 2, thickening type quaternary ammonium salt composition stability investigation and evaluation method
[0017] Unless otherwise stated, the following procedures were used for stability evaluation. The samples were placed in a 60°C oven. Measure the appearance properties and viscosity of the composition during the stability investigation, and in some cases also measure the content of benzyltrimethylammonium chloride active ingredient in the composition. Use the SYD-04 type full-automatic kinematic viscosity tester (produced by Jilin Dongfang Wei'an Science and Technology (Instrument) Co., Ltd.) to measure the viscosity of the composition, the viscosity unit is cP, and measure the content of benzyltrimethylammonium chloride by titrating with sodium tetraphenylborate concentration.
Embodiment 3
[0018] Embodiment 3, thickening type quaternary ammonium salt stability investigation test
[0019] This example shows the viscosity of a benzyltrimethylammonium chloride sample containing hypromellose thickener, fragrance and the variation of benzyltrimethylammonium chloride concentration therein. The following samples were prepared according to the general steps of Example 1, and the performance evaluation of the samples was carried out according to the stability investigation method of Example 2, and the results are listed in Table 1.
[0020] Sample 1 contained 10% benzyltrimethylammonium chloride and 0.6% hydroxypropyl cellulose.
[0021] Sample 2 contained 10% benzyltrimethylammonium chloride and 0.7% hydroxypropyl cellulose.
[0022] Sample 3 contained 10% benzyltrimethylammonium chloride and 0.9% hydroxypropyl cellulose.
[0023] Sample 4 contained 10% benzyltrimethylammonium chloride and 1.2% hydroxypropyl cellulose.
[0024] Table 1 Stability of benzyltrimethylamm...
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