Application of total aglycone of himalayan teasel roots and single-component hederagenin in medicaments preparing Alpha-glucosidase inhibitor

A technology of helexin and glucosidase, applied in the field of medicine, can solve the problem of not using silica gel column chromatography, ODS column chromatography, high performance liquid chromatography and the like

Active Publication Date: 2009-10-28
启东市天汾电动工具技术创新中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And after the ethanol extract is concentrated, pass through the macroporous resin column and elute with alkaline ethanol solution to remove some alkali-soluble impurities, and the prepared total saponins have higher purity, so that the total aglycone and single component of Dipsacus can be prepared Hedera saponin did not use silica gel column chromatography, ODS column chromatography, high performance liquid chromatography and other separation means

Method used

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  • Application of total aglycone of himalayan teasel roots and single-component hederagenin in medicaments preparing Alpha-glucosidase inhibitor
  • Application of total aglycone of himalayan teasel roots and single-component hederagenin in medicaments preparing Alpha-glucosidase inhibitor
  • Application of total aglycone of himalayan teasel roots and single-component hederagenin in medicaments preparing Alpha-glucosidase inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Preparation of Dipsacus total aglycon and hedera saponin

[0050] Take 1 kg of Dipsacus medicinal material, and reflux extract with 8 times the amount of 75% ethanol for 3 times. For 3 hours each time, combine the extracts three times, add 30g of calcium oxide, stir, stand overnight, filter, adjust the pH of the filtrate to 6-7 with dilute hydrochloric acid, add 200g of activated carbon, stir, filter, and recover ethanol from the filtrate until it is free of alcohol Add water to 2000ml, pass through the treated macroporous resin column, first wash 3 times the column volume with 20% ethanol with a pH value of 12, then wash with water until neutral, finally elute with 70% ethanol, collect 70% The eluate was concentrated to dryness under reduced pressure; hydrolyzed with 12 times the amount of 2N hydrochloric acid and 40% ethanol for 3 hours. Filtrate, discard the hydrolyzate, wash the filter cake with deionized water until neutral; then heat to boiling with 95...

Embodiment 2

[0051] Example 2 Preparation of Dipsacus total aglycon and hedera saponin

[0052] Take 1 kg of Dipsacus medicinal material, and reflux extract with 6 times the amount of 60% ethanol for 3 times. For 2 hours each time, combine the extracts three times, add 20g of calcium oxide, stir, stand overnight, filter, adjust the pH of the filtrate to 6-7 with dilute hydrochloric acid, add 100g of activated carbon, stir, filter, and recover the ethanol from the filtrate until it is free of alcohol Add water to 2000ml, pass through the treated macroporous resin column, first wash 4 times the column volume with 30% ethanol with a pH value of 13, then wash with water until neutral, finally elute with 60% ethanol, collect 60% The eluate was concentrated to dryness under reduced pressure; it was hydrolyzed with 10 times of 2N hydrochloric acid solution containing 45% ethanol for 3 hours. Filtrate, discard the hydrolyzate, wash the filter cake with deionized water until neutral; then heat t...

Embodiment 3

[0053] Example 3 (capsules)

[0054] 100g of hedera saponin or total aglycone of Dipsacus, appropriate amount of medicinal micropowder silica gel, mix evenly, granulate, dry, granulate, put into No. 1 capsule, make 1000 capsules, and get ready. 1 capsule each time, 2 times a day.

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PUM

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Abstract

The invention discloses a new application of total aglycone of himalayan teasel roots and single-component hederagenin in medicaments preparing Alpha-glucosidase inhibitor; the medicaments preparing the Alpha-glucosidase inhibitor can be the total aglycone of himalayan teasel roots, the single-component hederagenin, or a compound containing the total aglycone of himalayan teasel roots and the single-component hederagenin, which all can be prepared into tablets, capsules, granules, injections and suspensions.

Description

technical field [0001] The invention relates to a method for extracting the total aglycon of Dipsacus and the single component hedera saponin from the traditional Chinese medicine. It is proved by pharmacological experiments that the total aglycon of Dipsacus and the single component hedera saponin have new medical applications. Specifically, it relates to the application of the total aglycon of Dipsacus and the single component hedera saponin in the preparation of a drug for alpha-glucosidase inhibitors, and also relates to the pharmaceutical preparation of the drug. It belongs to the field of medical technology. Background technique [0002] Diabetes mellitus is a group of clinical syndromes caused by the interaction of genetic and environmental factors. It is due to the absolute or relative insufficiency of insulin secretion and the decreased sensitivity of target tissues to insulin, which causes a series of metabolism in the body such as sugar, fat, protein, water and el...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P3/10C07J63/00A61K31/56A61K125/00
Inventor 赵全成南敏伦赫玉芳马吉胜赵文杰
Owner 启东市天汾电动工具技术创新中心
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