The invention discloses a compound blood glucose reducing medicine composition and a preparing method thereof. The compound blood glucose reducing medicine composition is prepared from, by weight, 130-280 parts of hydrophilic polymer, 56-140 parts of allium victorialis ferment powder, 35-105 parts of silk peptide, 30-96 parts of fiddlehead powder, 30-68 parts of agar powder, 26-54 parts of maltotriose, 23-45 parts of cyclodextrin, 15-33 parts of sesamol, 12-28 parts of mixed enzyme, 10-25 parts of polypropylene glycol, 8-15 parts of betahistine, 6-15 parts of a retinoic acid compound, 5-12 parts of retinoic acid and 3-10 parts of niacin. According to the composition, multiple traditional Chinese medicine effective ingredients and western medicine ingredients are combined and act together to achieve the purpose of controlling increasing of blood glucose; moreover, various indexes of the body of a patient are increased, and cardiovascular health is protected; moreover, the medicine composition is small in side effect, and can not generate an adverse effect on the patient when the patient takes the composition for a long term. In addition, the raw materials of the medicine composition are easy to obtain, the preparation technology is simple, cost is low, economic burdens of the patient are reduced, and the composition is suitable for application and popularization.