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Cefmetazole preparation used for injection and preparation method thereof
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A technology of cefmetazole and cefmetazole acid, which is applied to the formulation and preparation of cefmetazole preparations, and can solve the problems of many impurities, low content, poor stability, etc.
Inactive Publication Date: 2009-11-11
张轶伦
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[0014] The purpose of the present invention is to provide a new preparation that overcomes the shortcomings of existing cefmetazole sodium preparations for injection such as poor stability, low content, and many impurities, which can improve product quality and product stability, and better ensure clinical drug use Safety
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[0041] Weigh the cefmetazole acid sterile powder and anhydrous sodium carbonate sterile powder according to the prescription amount, mix them evenly, and then pack them into aseptically treated vials, press the stopper, roll the cap, and pass the inspection. After packing.
[0042] The inspection results are shown in Table 3.
[0052] Weigh the cefmetazole acid sterile powder and anhydrous sodium carbonate sterile powder according to the prescription amount, mix them evenly, and then pack them into aseptically treated vials, press the stopper, roll the cap, and pass the inspection. After packing.
[0053] The inspection results are shown in Table 4.
[0063] Weigh the cefmetazole acid sterile powder and anhydrous sodium carbonate sterile powder according to the prescription amount, mix them evenly, and then pack them into aseptically treated vials, press the stopper, roll the cap, and pass the inspection. After packing.
[0064] The inspection results are shown in Table 5.
[0065] table 5
[0066] project
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Abstract
The invention provides a new cefmetazole preparation used for injection. The preparation mixes evenly active ingredient cefmetazole acid asepsispowder and complex solubilizer anhydroussodiumcarbonateasepsispowder which are respectively bottled in sterilized amoxicillin bottles according to labeled amount and are packaged to obtain the product of cefmetazole used for injection after tamponage, rolling of cover and full inspection; wherein the weight ratio between cefmetazole acid (pure) and anhydroussodiumcarbonate is 1:0.1 to 1:0.2 with 1:0.15 being the better ratio, namely, 1g of cefmetazole acid (pure) asepsispowder is added into 0.1-0.2g of anhydroussodiumcarbonate asepsis powder. The preparation is good in stability and safe in usage.
Description
technical field [0001] The invention relates to a formulation of cefmetazole preparation and a preparation method thereof, in particular to a formulation of injectable cefmetazole preparation and a preparation method thereof. Background technique [0002] Cefmetazole, chemical name: (6R,7S)-7-[2-[(cyanomethyl)thio]acetamido]-7-methoxy-3-[[(1-methyl-1H- Tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. [0003] Chemical Structure: [0004] [0005] Cefmetazole is a second-generation cefamycin antibacterial drug developed by Japan Sankyo Company. The pharmacodynamic feature of the drug is that the concentration difference between MIC and MBC is small, so the bactericidal ability is strong, the initial bactericidal effect is superior, and the antibacterial effect is balanced, and it has good antibacterial function against Gram-positive and Gram-negative bacteria; usually Cephamycins have a strong effect on Gram-negative bacteria, and ...
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