TcO nucleus marked ciprofloxacin dithiocarbamate complex and preparation method and applications thereof

A technology of ciprofloxacin and ammonium sulfate, applied in the fields of radiopharmaceutical chemistry and clinical nuclear medicine, can solve the problems of high uptake, low inflammation/muscle ratio, etc.
CN101574531AInactive Publication Date: 2009-11-11BEIJING NORMAL UNIVERSITY +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING NORMAL UNIVERSITY
Publication Date
2009-11-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a TcO nucleus marked ciprofloxacin dithiocarbamate complex and a preparation method and applications thereof. The complex uses the TcO nucleus as a central nucleus; and four sulphur atoms in two CPFXDTC ligand molecules generate complexation reaction with Tc to obtain a TcO-CPFXDTC complex. The complex has the advantages of high radiochemical purity, good stability, high intussusception of inflammation, rational target-to-nontarget ratio of inflammation to muscle, and low intussusception of liver, lung, spleen and the like. Therefore, the complex is a new developer of inflammation, with popularization and application values.
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Description

Technical field

[0001] The present invention relates to 99 Tc m O the field of radiopharmaceutical chemistry and clinical nuclear medicine technology for nuclear labeling, specifically relating to a 99 Tc m O nucleus-labeled ciprofloxacin dicarbaminate complex, its preparation method and application. Background technique

[0002] Nuclide inflammation imaging is an important method for early detection of lesions. Inflammation imaging agents are divided into proteins, antibiotics, leukocytes, and small molecule compounds according to different markers. The nuclides used are as follows: 67 Ga, 111 In and 99 Tc m . because 99 Tc m Excellent nuclear properties, cheap and easy to obtain and other advantages make it one of the preferred nuclides for radiopharmaceutical research. 99 Tc m Labeled white blood cell imaging is known as the "gold standard" for detecting acute and chronic inflammatory lesions, but the labeling process is complicated and cross-infection is prone...

Claims

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