Technetium-99m-labeled isonitrile-containing ferrichomide derivative as well as preparation method and application thereof

Abstract

The invention discloses a < 99m > Tc-labeled isonitrile-containing ferricyanide derivative and a preparation method and application thereof, ferricyanide with bacterial specificity (Ferrioxamine B) is converted into isonitrile ferricyanide (CNFO) capable of being complexed with < 99m > Tc, and a < 99m > Tc-CNFO complex is obtained through a preparation process that isonitrile groups in a CNFO ligand are coordinated with < 99m > Tc. The complex is a hydrophilic substance, is high in radiochemical purity, good in stability, simple and convenient to prepare, high in uptake and good in retention at bacterial inflammation parts, good in inflammation / muscle ratio, capable of distinguishing bacterial inflammation and non-bacterial inflammation, and capable of serving as a novel bacterial inflammation imaging agent to be popularized and applied.

Description

Technical field:

[0001] The invention relates to the technical fields of radiopharmaceutical chemistry and clinical nuclear medicine, in particular to a technetium-99m-labeled isonitrile-containing ferrioxamine derivative, a preparation method and an application. Background technique:

[0002] In recent years, nuclear medicine imaging such as Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) has been fully developed, and nuclear medicine imaging can accurately locate the lesion area , reflecting the pathophysiological changes of inflammation, it is helpful to find out the etiology and make a targeted treatment plan, with high sensitivity and strong specificity. With the development of nuclear medicine imaging, the preparation and development of safe and effective bacterial inflammation imaging agents has become an urgent need for current clinical research. Bacteria and other microorganisms have specific iron metabolism, and will secre...

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