Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Technetium-99m-labeled isonitrile-containing ferrichomide derivative as well as preparation method and application thereof

A technology for ferrioxamine and its derivatives, which is applied in the field of technetium-99m-labeled isocyanide-containing ferrioxamine derivatives and its preparation, achieving the effects of good stability, good inflammation/muscle ratio, and easy preparation

Active Publication Date: 2022-04-15
BEIJING NORMAL UNIVERSITY
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Technetium-99m-labeled ferrioxamine has not been reported as a radiopharmaceutical for the diagnosis of bacterial inflammation, so it is necessary to develop a new technetium-99m-labeled imaging agent for bacterial inflammation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Technetium-99m-labeled isonitrile-containing ferrichomide derivative as well as preparation method and application thereof
  • Technetium-99m-labeled isonitrile-containing ferrichomide derivative as well as preparation method and application thereof
  • Technetium-99m-labeled isonitrile-containing ferrichomide derivative as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0045] Describe the present invention in detail below by embodiment: a kind of 99m Tc-CNFO complex, its structural formula is as follows:

[0046]

[0047] In the structural formula: with 99m Tc + The core is the central core, and the carbon atom of the isonitrile in the CNFO ligand molecule and 99m Tc coordinates to form a hexacoordinated 99m Tc-CNFO complex. However, n represents an integer of 2 or more.

[0048] a. Synthesis of Ligand CNFO:

[0049] Weigh 6.4mg (0.16mmol) of sodium hydroxide in a round bottom flask, add 10mL of methanol to dissolve, then add 104mg (0.16mmol) of deferoxamine mesylate, after the dissolution is complete, dropwise add 69mg (0.24mmol) of the compound 1 (n=5) in dichloromethane solution, react overnight at room temperature, after the reaction, concentrate the mother liquor, precipitate out after cooling, filter to obtain a filter cake, wash with an appropriate amount of dichloromethane, and dry to obtain a white solid compound 2 (55mg) ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a < 99m > Tc-labeled isonitrile-containing ferricyanide derivative and a preparation method and application thereof, ferricyanide with bacterial specificity (Ferrioxamine B) is converted into isonitrile ferricyanide (CNFO) capable of being complexed with < 99m > Tc, and a < 99m > Tc-CNFO complex is obtained through a preparation process that isonitrile groups in a CNFO ligand are coordinated with < 99m > Tc. The complex is a hydrophilic substance, is high in radiochemical purity, good in stability, simple and convenient to prepare, high in uptake and good in retention at bacterial inflammation parts, good in inflammation / muscle ratio, capable of distinguishing bacterial inflammation and non-bacterial inflammation, and capable of serving as a novel bacterial inflammation imaging agent to be popularized and applied.

Description

Technical field: [0001] The invention relates to the technical fields of radiopharmaceutical chemistry and clinical nuclear medicine, in particular to a technetium-99m-labeled isonitrile-containing ferrioxamine derivative, a preparation method and an application. Background technique: [0002] In recent years, nuclear medicine imaging such as Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) has been fully developed, and nuclear medicine imaging can accurately locate the lesion area , reflecting the pathophysiological changes of inflammation, it is helpful to find out the etiology and make a targeted treatment plan, with high sensitivity and strong specificity. With the development of nuclear medicine imaging, the preparation and development of safe and effective bacterial inflammation imaging agents has become an urgent need for current clinical research. Bacteria and other microorganisms have specific iron metabolism, and will secre...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07F19/00C07B59/00A61K51/04A61K103/10
CPCY02P20/55
Inventor 张俊波江雨豪王倩娜王学斌唐志刚陆洁张站斌
Owner BEIJING NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com