Quasi-one-dimensional metal oxide nano-material biosensor and method for manufacturing same

A biosensor and nanomaterial technology, applied in the field of quasi-one-dimensional metal oxide nanomaterial biosensors and their fabrication, can solve long-term problems, often requiring more than a few hours, a certain number of samples, and the sensitivity needs to be improved. , to achieve the effect of improving sensitivity and detection speed, wide application range, and shortening sample preparation and processing time

Active Publication Date: 2009-12-02
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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Benefits of technology

This patented technology describes an improvement for making better ways to measure important health indicators like nitrogen monoxide (NO) levels that could lead to more effective treatments against various illnesses caused by these substances. By combining quantum dots with silica materials, this new technique allows for faster reaction times while also improving its ability to distinguish different types of harmful particles from each others. Overall, it provides technical benefits over current techniques including gas analysis and liquid phase extraction.

Problems solved by technology

This patents discusses various techniques used during medical testing that aim towards quicker and easier identification of important materials like small particles called microparticles or bacteria (bacillus) cells found inside blood vessels due to their ability to affect healthy tissues through interactions between these tiny objects and living organisms. Current technologies use antibodies or DNA probing technology but they may take too much longer and still only work within one hour after exposure. There're also concerns about potential safety hazards caused from excessive radiation dosage levels when analyzers measure low concentrations of specific compounds in airways lungs.

Method used

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  • Quasi-one-dimensional metal oxide nano-material biosensor and method for manufacturing same
  • Quasi-one-dimensional metal oxide nano-material biosensor and method for manufacturing same
  • Quasi-one-dimensional metal oxide nano-material biosensor and method for manufacturing same

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Effect test

Embodiment 1

[0059] Combination with DNA or RNA probes to detect viral diseases, such as Image 6 ; Specific process such as Figure 2 to Figure 5 .

[0060] Preparation of quasi-one-dimensional metal oxide semiconductor nanomaterials and device fabrication:

[0061] Synthesis of TiO by Solvothermal Method 2 and ZnO nanomaterials, take a certain proportion of reactants, stir rapidly, and react in an autoclave for 16-24 hours after cleaning.

[0062] Based on the VLS (gas-liquid-solid) growth mechanism, nanowires (ZnO or TiO 2 ), the length of the nanowire is controlled by controlling the gas flow rate, air pressure, and growth time, and the specific steps are as follows:

[0063] 1. Deposit a layer of Au film of about 1-10nm on the Si substrate by electron beam evaporation;

[0064] 2. Sprinkle 325-mesh Zn powder (99.999%) evenly on the quartz boat, and place the Si substrate deposited with the Au film upside down on the quartz boat;

[0065] 3. Turn on the mechanical pump and the mo...

Embodiment 2

[0084] Rapid diagnosis of myocardial infarction and acute pancreatitis, such as Figure 7 , the specific process is as Figure 2 to Figure 5 .

[0085] Preparation of quasi-one-dimensional metal oxide semiconductor nanomaterials and device fabrication:

[0086] Synthesis of TiO by Solvothermal Method 2 And ZnO nanomaterials. Take a certain proportion of reactants, stir rapidly, and react in an autoclave for 16-24 hours after cleaning.

[0087] The standard process of micro-nano photolithography is used to fabricate the contact electrodes of oxide nanomaterials.

[0088] Fabrication process and integration of quasi-one-dimensional metal oxide nanomaterial devices:

[0089] 1. Silica growth, such as figure 2 Shown; clean the silicon wafer, and form a silicon dioxide oxide layer 2 with a thickness of 100-400 nanometers on the surface of the silicon wafer 1 by thermal growth.

[0090] 2. Fabrication of the back gate, such as image 3 As shown; the position of the back gat...

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Abstract

The invention relates to a quasi-one-dimensional metal oxide nano-material biosensor and a method for manufacturing the same. The sensor comprises a silicon chip, a silicon dioxide oxidation layer grown on the silicon chip, a grid electrode, a source electrode, a drain electrode and a microfluid channel; and a quasi-one-dimensional metal oxide semiconductor nano-material is connected with the source electrode and the drain electrode to form a conduction channel. A process for the quasi-one-dimensional metal oxide nano-material biosensor comprises the following steps: firstly, synthesizing thequasi-one-dimensional metal oxide semiconductor nano-material; secondly, adopting a micro-nanometer photolithography standard process and a top-down method to manufacture the quasi-one-dimensional metal oxide semiconductor nano-material and a field effect transistor in array; thirdly, using polydimethylsiloxane to manufacture the microfluid channel; finally, performing surface modification on thequasi-one-dimensional metal oxide semiconductor nano-material, modifying a joining unilayer combined with a target molecule through a self-assembling method, and connecting biological molecules on the surface of the nano-material through joining molecules so as to detect a symbolic molecule of a disease. The quasi-one-dimensional metal oxide nano-material biosensor has the characteristics of rapid response, high sensitivity, strong selectivity, no labeled molecule and the like.

Description

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Claims

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Application Information

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Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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