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Method and system for estimating correlation of gene sequence and pharmacological reaction of medicament

A gene sequence and correlation technology, applied in the fields of genetic engineering and biomedical engineering, can solve the problems of poor drug targeting and inability to evaluate correlations, and achieve the effect of improving targeting

Inactive Publication Date: 2009-12-16
张俊 +3
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Problems solved by technology

[0005] One of the purposes of the present invention is to provide a system for evaluating the correlation between gene sequence and drug pharmacological response, aiming to solve the problem that the existing technology cannot evaluate the correlation between the drug pharmacological response and the disease, which leads to the subsequent treatment process. The problem of poor targeting of medication

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  • Method and system for estimating correlation of gene sequence and pharmacological reaction of medicament
  • Method and system for estimating correlation of gene sequence and pharmacological reaction of medicament
  • Method and system for estimating correlation of gene sequence and pharmacological reaction of medicament

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example

[0058] Taking advanced colorectal tumors as an example, the patent solution is described in detail. The specific process is as follows:

[0059] 1. Detect the gene sequences of all gene loci related to the curative effect of the therapeutic drug for the colorectal tumor. It is currently known that the commonly used drugs for colorectal tumors include 3 major classes of chemotherapy drugs (fluorouracils, oxaliplatin, and irinotecan) and 2 monoclonal antibodies (cetuximab and panitumumab targeting EGFR, Bevacizumab against VEGF). Commonly used clinical regimens include any combination of the above-mentioned various drugs.

[0060] The genes related to the efficacy of the above-mentioned various drugs are shown in the table below:

[0061] drug

Gene sequences associated with drug efficacy

Fluorouracils

TS, DPD, TP, MSI, MTHFR expression / gene polymorphism

irinotecan

UGT polymorphisms, MSI, transporter polymorphism

Oxaliplatin

ERCC1,...

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Abstract

The invention relates to the fields of gene engineering and biomedical engineering, and provides a method and a system for estimating correlation of gene sequence and pharmacological reaction of a medicament. The method comprises the following steps: A, detecting the gene sequence of gene locus related with a disease and / or the pharmacological reaction of the medicament for treating the disease; B, searching gene sequence which is consistent with the detected gene sequence in a database, and extracting corresponding medicament correlation data; and C, generating a medicament estimation result according to the medicament correlation data, and outputting the medicament estimation result. The system comprises the database, a gene sequence detection unit, a data processing unit and an output unit. The method and the system confirm the correlation between the pharmacological reaction of the medicament and the disease so as to improve the medication pertinency in a follow-up treatment process.

Description

technical field [0001] The present invention relates to the fields of genetic engineering and biomedical engineering, and more specifically relates to a method and system for evaluating the correlation between gene sequence and drug pharmacological response. Background technique [0002] In the current medical technology, it is generally possible to diagnose the disease. However, it is not clear whether many drugs currently in use are effective for the disease, which is especially common in diseases such as tumors. In addition, due to individual differences in patients, it is not clear whether the drug will cause adverse reactions in different situations. [0003] It can be seen from the above that the existing technology cannot clarify the correlation between the pharmacological response of the drug (including curative effect and adverse reactions) and the disease, and only empirical medication can be used in the subsequent treatment process, and this method is based on po...

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Application Information

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IPC IPC(8): C12Q1/68G06F17/30
Inventor 张俊盛司潼朱正纲计骏
Owner 张俊
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