Method for removing gram negative bacilli by using piperacillin and tazobactam compound preparation

Abstract

The invention discloses a method for removing gram negative bacilli by using a piperacillin and tazobactam compound preparation. In the method, the compound preparation is used for removing the gram negative bacilli for 3 to 4 times every day, the dose of the compound preparation used for each time is 4.5g, the compound preparation is injected after being dissolved by using 20ml to 50ml of physiological water, and the injecting time of the compound preparation is 3 hours for each time, so that the compound preparation can reach the dose of effectively removed gram negative bacilli in the time of at least 3 hours, the sterilization and removing time of the effective dose is longer than that of a conventional method, the degeneracy of medicines with the same dose is moderated, the utilization rate of the medicines is enhanced, and the removing rate is enhanced and can reach more than 40%; the effective rate to infected patients is also enhanced obviously and can reach 66.7%; The the method for removing the gram negative bacilli by using the piperacillin and tazobactam compound preparation of the has higher bacterium removing rate and higher effective rate for clinically treating the patient infected with the gram negative bacilli.

Description

Technical field [0001] The invention relates to a method for removing gram-negative bacilli, in particular to a method for removing gram-negative bacilli with a piperacillin tazobactam compound preparation. Background technique [0002] Gram-negative bacilli (G - Bacillus) such as Escherichia coli, Enterobacter cloacae, Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumonia, etc., are the main pathogenic bacteria of hospital infections. G - The proportion of bacilli is larger. With the widespread application of antibacterial drugs, most G - The drug resistance of bacilli is increasing year by year, and gram-negative bacilli are prone to become resistant to antibiotics, and the production of β-lactamases (ESBLs) is the main mechanism of their resistance, and there are fewer and fewer drugs available for clinical selection. Piperacillin·tazobactam is a compound preparation of β-lactams and β-lactamase inhibitors. The general market specification is 4.5g / bottle (in...

AI Technical Summary

Problems solved by technology

However, the current clinical or experimental method of using the piperacillin-tazobactam compound preparation to eliminate gram-negative bacilli is as follows: 3 to 4 times a day, with a dosage of 4.5g each time, and 20 to 50ml of physiological water, etc. Infusion after dissolving, each infusion time is not longer than 30min, the bacterial clearance rate of this method for Gram-negative bacilli can only reach 31%, and the effective rate of treatment for patients with clinical Gram-negative bacilli is only 40.7%

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