Carboxymethyl chitosan/polyvinyl alcohol compound sponge and preparation method thereof

A technology of carboxymethyl chitosan and polyvinyl alcohol, used in medical science, absorbent pads, prostheses, etc., to achieve the effects of good elasticity, good biocompatibility and high water absorption

Inactive Publication Date: 2010-02-24
湖北中创医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are few reports on polyvinyl alcohol porous sponge at home and abroad, mainly focusing on the res

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Add polyvinyl alcohol and carboxymethyl chitosan according to the percentage by weight of each raw material: 23% polyvinyl alcohol and 10% carboxymethyl chitosan, add them to a three-necked bottle, reflux and dissolve at 90°C for 30 minutes, Pour the solution into a beaker and add 33% sulfuric acid, 26% formaldehyde and 8% foaming agent. After fully mechanically stirring, the blend is poured into a mold, and thermoformed in an oven at 50°C for 4 hours to obtain a composite sponge sample ( A carboxymethyl chitosan / polyvinyl alcohol composite sponge material).

Embodiment 2

[0021] Add polyvinyl alcohol and carboxymethyl chitosan according to the percentage by weight of each raw material: 25% polyvinyl alcohol and 15% carboxymethyl chitosan are added to a three-necked bottle, and after condensing and refluxing at 90°C for 35 minutes, the Pour the solution into a beaker and add 29% of sulfuric acid, 24% of formaldehyde and 7% of foaming agent. After fully mechanically stirring, the blend is poured into a mold, and thermoformed in an oven at 60°C for 6 hours to obtain a composite sponge sample (one A carboxymethyl chitosan / polyvinyl alcohol composite sponge material).

Embodiment 3

[0023] Add polyvinyl alcohol and carboxymethyl chitosan according to the percentage by weight of each raw material: 26% polyvinyl alcohol and 13% carboxymethyl chitosan are added to a three-necked bottle, and after condensing and refluxing at 90°C for 40 minutes, the Pour the solution into a beaker and add 28% hydrochloric acid, 25% formaldehyde and 8% foaming agent. After fully mechanically stirring, the blend is poured into a mold, and thermoformed in an oven at 60°C for 8 hours to obtain a composite sponge sample (one A carboxymethyl chitosan / polyvinyl alcohol composite sponge material).

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PUM

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Abstract

The invention relates to carboxymethyl chitosan/polyvinyl alcohol compound sponge which is prepared by taking carboxymethyl chitosan and polyvinyl alcohol as raw materials, wherein the weight percentof each raw material is as follows: 8-17% of carboxymethyl chitosan, 23-26% of polyvinyl alcohol, 28-33% of acid, 23-26% of formaldehyde and 7-8% of foaming agent. The preparation method of the carboxymethyl chitosan/polyvinyl alcohol compound sponge comprises the following steps: heat dissolving the polyvinyl alcohol, acetalating, foaming and compounding with the carboxymethyl chitosan; when preparing, selecting the high-viscosity polyvinyl alcohol which has the polymerization degree of 2000-2600 and is in complete alcoholysis or is in incomplete alcoholysis as the raw material, dissolving the carboxymethyl chitosan and the polyvinyl alcohol, then adding the acid, the formaldehyde and the foaming agent, mixing together, heating in a baking oven, forming and obtaining the compound sponge.The invention can prepare the compound sponge with superior water-absorption and mechanical properties and good biocompatibility and has the advantages of low cost, environmental protection, simple process and the like, and the obtained material can be used for treating wound cavity infection, burns, skin grafting and the like.

Description

technical field [0001] The invention relates to the field of polymer material science, and also belongs to the field of natural polymers, in particular to a carboxymethyl chitosan / polyvinyl alcohol composite sponge and a preparation method thereof. Background technique [0002] Chitosan has good biocompatibility, bioadhesion and various biological activities. It is non-toxic and non-immune. It can be biodegraded by various enzymes in the body. The degradation products are non-toxic and can be completely absorbed by organisms. Ideal carrier for interpretation. However, chitosan is only soluble in acidic aqueous solution, which limits its application range. As a derivative of chitosan, carboxymethyl chitosan not only retains the advantages of chitosan, but also greatly improves water solubility. At the same time, due to the introduction of carboxymethyl groups, it has more biological activity and It has better biocompatibility and has multiple uses in medicine and other fiel...

Claims

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Application Information

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IPC IPC(8): C08L29/14C08L5/08C08J9/08A61L15/28A61L15/24A61L15/42A61L27/40A61L27/54A61L27/56A61L27/60
Inventor 宋炜樊李红周月
Owner 湖北中创医疗用品有限公司
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