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Method of treating diabetes

A technology for diabetes and prediabetes, applied in the field of diabetes treatment, can solve problems such as suboptimal treatment

Inactive Publication Date: 2010-03-03
GILEAD SCI INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these treatments are not ideal

Method used

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  • Method of treating diabetes
  • Method of treating diabetes
  • Method of treating diabetes

Examples

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preparation example Construction

[0335] Sterile injectable solutions are prepared by incorporating the ingredients in the required amount in the appropriate solvent with various other ingredients from those enumerated above, if desired, followed by filtered sterilization. Generally, dispersions are prepared by incorporating the various sterilized active ingredients into a sterile vehicle which contains the basic dispersion medium and the required other ingredients from those enumerated above. In the case of sterile powders for the preparation of sterile injectable solutions, the preferred methods of preparation are by vacuum drying and freeze-drying techniques, which yield a powder of the active ingredient plus any additional desired ingredient from a previously sterile-filtered solution. .

[0336] Oral administration is another route for administering these ingredients. Administration can be via capsules or enteric-coated tablets, or the like. In preparing pharmaceutical compositions comprising at least o...

Embodiment 1

[0379] Prepare hard capsules containing:

[0380] quantity

[0381] Element (mg / capsule)

[0382] Active ingredient 30.0

[0383] Starch 305.0

[0384] Magnesium Stearate 5.0

[0385] The above ingredients are mixed and filled into hard gel capsules.

Embodiment 2

[0387] Tablets are prepared with the following ingredients:

[0388] Element (mg / tablet)

[0389] Active ingredient 25.0

[0390] Cellulose, microcrystalline 200.0

[0391] Colloidal silicon dioxide 10.0

[0392] Stearic acid 5.0

[0393] The ingredients are mixed and compressed to form tablets.

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Abstract

Methods are provided for treating diabetes, lowering plasma level of HbA1c, glucose plasma levels, total cholesterol plasma level, and / or triglyceride plasma level while increasing HDL cholesterol levels and delaying onset of diabetic retinopathy in a diabetic, pre-diabetic, or non-diabetic mammal while minimizing undesirable side effects. The invention comprises administration of a partial fattyacid inhibitor such as ranolazine.

Description

[0001] This application is a divisional application of the invention patent application submitted on May 21, 2003 with the application number 03811323.6 (the original PCT application number is PCT / US2003 / 016277) and the invention title is "method for treating diabetes". This application claims priority to U.S. Provisional Application No. 60 / 382,781, filed May 21, 2002, and U.S. Provisional Application No. 60 / 459,332, filed March 31, 2003, the entire disclosures of which are incorporated in This is for reference. technical field [0002] The present invention provides methods for treating diabetes by reducing plasma levels of HbA1c, plasma glucose, plasma total cholesterol, and / or plasma triglycerides while increasing HDL cholesterol, and in diabetic, prediabetic, or non-diabetic mammals A method to delay the onset of diabetic retinopathy while minimizing unwanted side effects. Background technique [0003] Diabetes mellitus is a disease characterized by: high blood sugar; a...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/495A61K31/496A61P3/06A61P3/10A61KA61P
Inventor 安德鲁·沃尔夫马库斯·耶林
Owner GILEAD SCI INC
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