Method for separating alkene effective constituents in ginger essential oil

A technology of ginger essential oil and active ingredients, which is applied in the directions of medical preparations containing active ingredients, organic active ingredients, ion exchange regeneration, etc. Ginger essential oil alkene components and other issues, to achieve the effect of short cycle, good separation and simple process

Inactive Publication Date: 2013-01-09
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent CN1762956A discloses a method for preparing total gingerols by supercritical column chromatography, but does not mention the alkene components in ginger essential oil
Summarizing the existing literature, there is no report on the separation of various olefinic substances in ginger essential oil or ginger oleoresin, nor any report on the separation process of olefinic components with industrialization prospects

Method used

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  • Method for separating alkene effective constituents in ginger essential oil
  • Method for separating alkene effective constituents in ginger essential oil
  • Method for separating alkene effective constituents in ginger essential oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh 5g of ginger essential oil, add 10g of absolute ethanol to dissolve, then add 8g of chromatographic silica gel with a particle size of 48-75μm, remove the solvent after stirring evenly, and obtain silica gel with ginger essential oil absorbed; another 180g of chromatographic silica gel is loaded into the chromatography In the column, the silica gel adsorbed with ginger essential oil is placed on the top of the chromatography column, and the volume ratio of the mixed eluent ether and n-hexane is 2:98, and the β-phellandrene, zingiberene and α-curcumene are collected successively. The three-stage eluate; the three-stage eluate is concentrated respectively to obtain three products: the relative contents of the main components in the product are respectively: the first concentrated product contains β-phellandrene 79.76%, and the second concentrated The product contains 94.91% zingiberene, and the third concentrated product contains 75.85% α-curcumene and 14.29% β-bisab...

Embodiment 2

[0023] Weigh 7g of ginger essential oil, add 30g of absolute ethanol to dissolve, then add 30g of chromatographic silica gel with a particle size of 48-75μm, stir evenly and remove the solvent to obtain silica gel with ginger essential oil absorbed; another 180g of chromatographic silica gel is loaded into the chromatography column In the process, the silica gel adsorbed with ginger essential oil was placed on the top of the chromatographic column, and the volume ratio of the mixed eluent diethyl ether and petroleum ether was 5:95. The three-stage eluate; the three-stage eluate is concentrated respectively to obtain three products: the first product contains β-phellandrene 78.37%, the second product contains zingiberene 93.41%, and the third product contains α-phellandrene Curcumene 66.22%, β-bisabolene 20.92%.

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Abstract

The invention relates to a method for separating a natural active product, in particular to a method for separating various alkene effective constituents in ginger essential oil by column chromatography, which comprises the following steps: quantitatively weighing the ginger essential oil, adding absolute ethyl alcohol to dissolve the ginger essential oil, adding chromatographic silica gel with the granularity of 48-75 mu m, and evenly stirring to remove the solvent so as to obtain the silica gel absorbed with the ginger essential oil; filling some other chromatographic silica gel into a chromatographic column, putting the silica gel absorbed with the ginger essential oil on the top end of the chromatographic column, eluting with a mixed eluent of aether and n-hexane or sherwood oil in volume ratio of 2-5:98-95, and orderly collecting three eluents respectively containing beta-phellandrene, zingiberene and alpha-curcumene in three stages; and concentrating the three eluents in three stages to obtain three concentrating products respectively mainly containing beta-phellandrene, zingiberene, alpha-curcumene and beta-bisabolene. The method has the advantages of simple technique, short period and easy realization of industrialization.

Description

1. Technical field [0001] The invention relates to a method for separating natural active products, in particular to a method for separating various alkene active components in ginger essential oil by column chromatography. 2. Technical background [0002] Ginger essential oil is a volatile component obtained from the fresh rhizome of Zingiber officinale Rosc. by means of steam distillation, pressing, supercritical carbon dioxide extraction, etc. It is a brown oily liquid with a strong aroma and spicy taste of ginger. In the early days, it was mainly used as a flavoring agent for food and beverages, and it was also an important flavor raw material. Now its medicinal value is gradually being paid attention to. [0003] Ginger essential oil mainly contains two major components of alkenes and phenols. Alkenes include gingerene, α-curcumene, β-bisabolene, β-phellandrene, β-sesquiphellandrene and other components. Also includes multiple ingredients. Each component has certain b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C13/21C07C13/23C07C7/12B01D15/08A61K31/015A61P15/00
Inventor 杜爱玲贾雁高杜爱琴王艳
Owner SHANDONG UNIV
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